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- W3095043379 abstract "Purpose: The role of protein 9 (CARD9) in the caspase recruitment domain in tumors is controversial. Our previous research found that CARD9 was significantly reduced in malignant pleural effusions. In this research, we further studied the role of CARD9 in NSCLC and its working mechanism. Materials and Methods: TCGA database and our own clinical specimen of NSCLC tested by immunohistochemistry, western blot and qRT-PCR were used to analyze the expression of CARD9 in NSCLC, Inhibition on signaling was performed to see the dependent pathway of CARD9 to mediate NSCLC malignant biological characteristics. Results: We found that CARD9 was decreased in human NSCLC tissues compared with normal tissues and low CARD9 expression was associated with poor survival. CARD9 was expressed in both tumor cells and macrophages in NSCLC tissues. Downregulation of CARD9 in NSCLC cells enhanced the abilities of proliferation, invasion and migration via activated MAPK p38 signaling while the ectopic expression of CARD9 presented an anti-tumor effect. BCL was identified to be the interacting protein of CARD9. Conclusion: We demonstrated that CARD9 was an independent factor for prognosis in NSCLC patients, and inhibited ability of proliferation, migration and invasion via regulation of MAPK/p38 pathway in NSCLC cells. Thus, CARD9 may serve as a potential target for treatment in NSCLC patients." @default.
- W3095043379 created "2020-11-09" @default.
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- W3095043379 date "2020-09-07" @default.
- W3095043379 modified "2023-10-16" @default.
- W3095043379 title "Caspase recruitment domain containing protein 9 suppresses non-small cell lung cancer proliferation and invasion via inhibiting MAPK/p38 pathway" @default.
- W3095043379 doi "https://doi.org/10.1183/13993003.congress-2020.1657" @default.
- W3095043379 hasPublicationYear "2020" @default.
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