FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3095091286> ?p ?o ?g. }

• W3095091286 abstract "Osteochondral lesions (OL) are a common clinical problem for orthopedic surgeons worldwide and are associated with multiple clinical scenarios ranging from trauma to osteonecrosis. OL vary from chondral lesions in that they involve the subchondral bone and chondral surface, making their management more complex than an isolated chondral injury. Subchondral bone involvement allows for a natural healing response from the body as marrow elements are able to come into contact with the defect site. However, this repair is inadequate resulting in fibrous scar tissue. The second differentiating feature of OL is that damage to the subchondral bone has deleterious effects on the mechanical strength and nutritive capabilities to the chondral joint surface. The clinical solution must, therefore, address both the articular cartilage as well as the subchondral bone beneath it to restore and preserve joint health. Both cartilage and subchondral bone have distinctive functional requirements and therefore their physical and biological characteristics are very much dissimilar, yet they must work together as one unit for ideal joint functioning. In the past, the obvious solution was autologous graft transfer, where an osteochondral bone plug was harvested from a non-weight bearing portion of the joint and implanted into the defect site. Allografts have been utilized similarly to eliminate the donor site morbidity associated with autologous techniques and overall results have been good but both techniques have their drawbacks and limitations. Tissue engineering has thus been an attractive option to create multiphasic scaffolds and implants. Biphasic and triphasic implants have been under explored and have both a chondral and subchondral component with an interface between the two to deliver an implant which is biocompatible and emulates the osteochondral unit as a whole. It has been a challenge to develop such implants and many manufacturing techniques have been utilized to bring together two unalike materials and combine them with cellular therapies. We summarize the functions of the osteochondral unit and describe the currently available management techniques under study." @default.
• W3095091286 created "2020-11-09" @default.
• W3095091286 creator A5004883979 @default.
• W3095091286 creator A5024893677 @default.
• W3095091286 creator A5047347330 @default.
• W3095091286 date "2020-11-04" @default.
• W3095091286 modified "2023-10-12" @default.
• W3095091286 title "Osteochondral Injury, Management and Tissue Engineering Approaches" @default.
• W3095091286 cites W1458137782 @default.
• W3095091286 cites W1529276587 @default.
• W3095091286 cites W1541101179 @default.
• W3095091286 cites W1544751778 @default.
• W3095091286 cites W1555813182 @default.
• W3095091286 cites W1744278994 @default.
• W3095091286 cites W1778992935 @default.
• W3095091286 cites W1795940530 @default.
• W3095091286 cites W1905497306 @default.
• W3095091286 cites W1923710437 @default.
• W3095091286 cites W1954624720 @default.
• W3095091286 cites W1965665343 @default.
• W3095091286 cites W1967880811 @default.
• W3095091286 cites W1969024375 @default.
• W3095091286 cites W1969054970 @default.
• W3095091286 cites W1969230575 @default.
• W3095091286 cites W1969696192 @default.
• W3095091286 cites W1972480348 @default.
• W3095091286 cites W1973343738 @default.
• W3095091286 cites W1974163213 @default.
• W3095091286 cites W1974323483 @default.
• W3095091286 cites W1974382774 @default.
• W3095091286 cites W1975775804 @default.
• W3095091286 cites W1978511310 @default.
• W3095091286 cites W1982355469 @default.
• W3095091286 cites W1982773621 @default.
• W3095091286 cites W1984642302 @default.
• W3095091286 cites W1985606434 @default.
• W3095091286 cites W1986233240 @default.
• W3095091286 cites W1986921424 @default.
• W3095091286 cites W1987547674 @default.
• W3095091286 cites W1990185161 @default.
• W3095091286 cites W1990615197 @default.
• W3095091286 cites W1990620069 @default.
• W3095091286 cites W1992442994 @default.
• W3095091286 cites W1993895799 @default.
• W3095091286 cites W1995010807 @default.
• W3095091286 cites W1995120265 @default.
• W3095091286 cites W1995122819 @default.
• W3095091286 cites W1995527685 @default.
• W3095091286 cites W1996499787 @default.
• W3095091286 cites W2011038175 @default.
• W3095091286 cites W2013597581 @default.
• W3095091286 cites W2013825234 @default.
• W3095091286 cites W2014566223 @default.
• W3095091286 cites W2017729170 @default.
• W3095091286 cites W2021420116 @default.
• W3095091286 cites W2021842516 @default.
• W3095091286 cites W2028610647 @default.
• W3095091286 cites W2031613531 @default.
• W3095091286 cites W2033644053 @default.
• W3095091286 cites W2035209595 @default.
• W3095091286 cites W2037328562 @default.
• W3095091286 cites W2037614138 @default.
• W3095091286 cites W2038153975 @default.
• W3095091286 cites W2038243239 @default.
• W3095091286 cites W2038641983 @default.
• W3095091286 cites W2042065329 @default.
• W3095091286 cites W2042788359 @default.
• W3095091286 cites W2044655193 @default.
• W3095091286 cites W2046084383 @default.
• W3095091286 cites W2047331853 @default.
• W3095091286 cites W2048489660 @default.
• W3095091286 cites W2050273631 @default.
• W3095091286 cites W2052356779 @default.
• W3095091286 cites W2052824814 @default.
• W3095091286 cites W2055512234 @default.
• W3095091286 cites W2059653038 @default.
• W3095091286 cites W2060112963 @default.
• W3095091286 cites W2060693812 @default.
• W3095091286 cites W2061507020 @default.
• W3095091286 cites W2061672809 @default.
• W3095091286 cites W2068253431 @default.
• W3095091286 cites W2069165747 @default.
• W3095091286 cites W2070360264 @default.
• W3095091286 cites W2070653298 @default.
• W3095091286 cites W2073229533 @default.
• W3095091286 cites W2074528940 @default.
• W3095091286 cites W2074800593 @default.
• W3095091286 cites W2077388592 @default.
• W3095091286 cites W2079691345 @default.
• W3095091286 cites W2080948384 @default.
• W3095091286 cites W2081787591 @default.
• W3095091286 cites W2083256869 @default.
• W3095091286 cites W2084028361 @default.
• W3095091286 cites W2084565323 @default.
• W3095091286 cites W2084849128 @default.
• W3095091286 cites W2087418982 @default.
• W3095091286 cites W2089567262 @default.
• W3095091286 cites W2091298400 @default.
• W3095091286 cites W2092156139 @default.
• W3095091286 cites W2093071023 @default.

• next