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- W3095095360 abstract "In this thesis, we present a study of cargo transport or behaviors in a cell byclusters of molecular motors on a single and many parallel or anti-parallel mi-crotubules. Molecular motors can be processive motors or non-processive motorswhich can bind on and o� and switch between microtubules (lanes). Our study in-cludes analytical theory, simulations and a detailed comparison with experiments.We extend the analytic expressions for the non-processive motors to the case of�nite binding sites on a single lane and multiple lanes, as presented in chapter ofone-lane and many-lane model, respectively. We performed Monte Carlo latticedbased stochastic simulations to validate the corresponding system. The simula-tions also include simple exclusion process and sequence preservation of motors.Our results show that the limiting number of binding sites along the lanes and se-quence preservation reduce the probability of non-processive motors binding, buthas a relatively small e�ect on the velocity. Multiple-lane transport can enhancethe velocity and averaged run length and reduce the delivery time. We also studycargo behaviour using a tug-of-war model in which the lanes on which motors stepare oriented in anti-parallel arrays between right and left ends of the cargo, as pre-sented in chapter of cargo deformation. This mechanism generates motor pullingforce onto the cargo which results in changing its shape and position. The cargocan be any cargoes acting as a spring and the nucleus is the example of cargo thatwe are interested in. This model provides new insights of nuclear deformation anddisplacement caused by the motor pulling force. Our simulations show that thedeformation and displacement can be induced by the increasing number of mi-crotubules. This corresponds with the experimental results of Susana Godinho'sgroup." @default.
- W3095095360 created "2020-11-09" @default.
- W3095095360 creator A5062145217 @default.
- W3095095360 date "2020-08-01" @default.
- W3095095360 modified "2023-09-27" @default.
- W3095095360 title "Modelling Cargo Transport and Deformation by Molecular Motors along Cytoskeletal Filaments" @default.
- W3095095360 hasPublicationYear "2020" @default.
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