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- W3095103147 abstract "Gastric cancer (GC) is the third most common cause of cancer-related death in the word. Immunotherapy is a promising treatment of cancer. However, it is unclear which GC subpopulation would benefit most from immunotherapy and it is necessary to develop effective biomarkers for predicting immunotherapy response. Nicotinamide N-methyltransferase (NNMT) is a metabolic regulator of CAF differentiation and cancer progression. In this study, we explored the correlations of NNMT to tumor-infiltrating immune cells (TIICs) and immune marker sets in STAD. Subsequently, we screened the NNMT correlated genes and performed the enrichment analysis of these genes. We eventually predicted the 19 most potential small-molecule drugs using the connectivity map (CMap) and Comparative Toxicogenomics Database (CTD). Also, nadolol, tranexamic acid, felbinac and dapsone were considered the four most promising drugs for GC. In summary, NNMT can be used as a prognostic biomarker that reflect immune infiltration level and a novel therapeutic target in GC." @default.
- W3095103147 created "2020-11-09" @default.
- W3095103147 creator A5003404928 @default.
- W3095103147 creator A5005914122 @default.
- W3095103147 creator A5016687275 @default.
- W3095103147 creator A5051555351 @default.
- W3095103147 creator A5075082039 @default.
- W3095103147 date "2020-10-28" @default.
- W3095103147 modified "2023-10-11" @default.
- W3095103147 title "Nicotinamide N-Methyltransferase Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric Cancer" @default.
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- W3095103147 doi "https://doi.org/10.3389/fgene.2020.580299" @default.
- W3095103147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7655872" @default.