Matches in SemOpenAlex for { <https://semopenalex.org/work/W3095167891> ?p ?o ?g. }
- W3095167891 endingPage "670" @default.
- W3095167891 startingPage "663" @default.
- W3095167891 abstract "It remains unclear whether serum lipids influence colorectal cancer (CRC) risk.We conducted a prospective cohort study of 380,087 adults aged 40-69 years in the UK Biobank. Serum high-density cholesterol, low-density cholesterol, total cholesterol, triglycerides, and apolipoprotein A and B were measured. We used Cox proportional hazard models to estimate the multivariable hazard ratios (HRs) of CRC according to one standard deviation (SD) increment in serum lipids. We conducted subgroup analysis by tumour anatomical subsites.During a median of 10.3 years of follow-up, we documented 2667 incident CRC cases. None of the lipid biomarkers was associated with the risk of CRC after adjusting for potential confounding factors, including body mass index and waist circumference. When assessed by cancer subsites, serum triglycerides was associated with an increased risk of cancer in the caecum and transverse colon, with the HR of 1.12 (95% CI, 1.00-1.25) and 1.29 (95% CI, 1.09-1.53), respectively; and apolipoprotein A was associated with a lower risk of hepatic flexure cancer (HR, 0.73, 95% CI, 0.56-0.96).Serum lipid profiles were not associated with colorectal cancer risk after adjusting for obesity indicators. The potential subsite-specific effects of triglycerides and apolipoprotein A require further confirmation." @default.
- W3095167891 created "2020-11-09" @default.
- W3095167891 creator A5017604004 @default.
- W3095167891 creator A5040016723 @default.
- W3095167891 creator A5079687568 @default.
- W3095167891 date "2020-11-03" @default.
- W3095167891 modified "2023-10-09" @default.
- W3095167891 title "Serum lipid profiles and risk of colorectal cancer: a prospective cohort study in the UK Biobank" @default.
- W3095167891 cites W129697205 @default.
- W3095167891 cites W1589037809 @default.
- W3095167891 cites W1824186052 @default.
- W3095167891 cites W1964176199 @default.
- W3095167891 cites W1969456163 @default.
- W3095167891 cites W1985399572 @default.
- W3095167891 cites W1985800111 @default.
- W3095167891 cites W1987608603 @default.
- W3095167891 cites W1990436525 @default.
- W3095167891 cites W1994518954 @default.
- W3095167891 cites W2000414851 @default.
- W3095167891 cites W2005839559 @default.
- W3095167891 cites W2016806069 @default.
- W3095167891 cites W2035738326 @default.
- W3095167891 cites W2048471397 @default.
- W3095167891 cites W2054136354 @default.
- W3095167891 cites W2077466352 @default.
- W3095167891 cites W2082704080 @default.
- W3095167891 cites W2084954009 @default.
- W3095167891 cites W2086909863 @default.
- W3095167891 cites W2098609251 @default.
- W3095167891 cites W2107573947 @default.
- W3095167891 cites W2114371152 @default.
- W3095167891 cites W2118224153 @default.
- W3095167891 cites W2118800077 @default.
- W3095167891 cites W2127167918 @default.
- W3095167891 cites W2144888610 @default.
- W3095167891 cites W2155955426 @default.
- W3095167891 cites W2167837946 @default.
- W3095167891 cites W2183695321 @default.
- W3095167891 cites W2252671082 @default.
- W3095167891 cites W2379931407 @default.
- W3095167891 cites W2464128201 @default.
- W3095167891 cites W2510411424 @default.
- W3095167891 cites W2543412381 @default.
- W3095167891 cites W2551647589 @default.
- W3095167891 cites W2556468825 @default.
- W3095167891 cites W2569086487 @default.
- W3095167891 cites W2626439516 @default.
- W3095167891 cites W2736848882 @default.
- W3095167891 cites W2742617701 @default.
- W3095167891 cites W2761480915 @default.
- W3095167891 cites W2883015258 @default.
- W3095167891 cites W2890117231 @default.
- W3095167891 cites W2896926952 @default.
- W3095167891 cites W2899186366 @default.
- W3095167891 cites W2901766631 @default.
- W3095167891 cites W2907317928 @default.
- W3095167891 cites W2916317774 @default.
- W3095167891 cites W2918477366 @default.
- W3095167891 cites W2969640860 @default.
- W3095167891 cites W2970045605 @default.
- W3095167891 cites W2972513114 @default.
- W3095167891 cites W2978077164 @default.
- W3095167891 cites W2982157011 @default.
- W3095167891 cites W2982418088 @default.
- W3095167891 cites W2990992250 @default.
- W3095167891 cites W2993314083 @default.
- W3095167891 cites W3006497234 @default.
- W3095167891 cites W3014259098 @default.
- W3095167891 cites W3015171497 @default.
- W3095167891 cites W3022258762 @default.
- W3095167891 doi "https://doi.org/10.1038/s41416-020-01143-6" @default.
- W3095167891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7851156" @default.
- W3095167891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33139801" @default.
- W3095167891 hasPublicationYear "2020" @default.
- W3095167891 type Work @default.
- W3095167891 sameAs 3095167891 @default.
- W3095167891 citedByCount "17" @default.
- W3095167891 countsByYear W30951678912021 @default.
- W3095167891 countsByYear W30951678912022 @default.
- W3095167891 countsByYear W30951678912023 @default.
- W3095167891 crossrefType "journal-article" @default.
- W3095167891 hasAuthorship W3095167891A5017604004 @default.
- W3095167891 hasAuthorship W3095167891A5040016723 @default.
- W3095167891 hasAuthorship W3095167891A5079687568 @default.
- W3095167891 hasBestOaLocation W30951678911 @default.
- W3095167891 hasConcept C121608353 @default.
- W3095167891 hasConcept C126322002 @default.
- W3095167891 hasConcept C134018914 @default.
- W3095167891 hasConcept C143998085 @default.
- W3095167891 hasConcept C188816634 @default.
- W3095167891 hasConcept C201903717 @default.
- W3095167891 hasConcept C207103383 @default.
- W3095167891 hasConcept C2776193436 @default.
- W3095167891 hasConcept C2778163477 @default.
- W3095167891 hasConcept C2780221984 @default.
- W3095167891 hasConcept C44249647 @default.
- W3095167891 hasConcept C50382708 @default.
- W3095167891 hasConcept C50440223 @default.