Matches in SemOpenAlex for { <https://semopenalex.org/work/W3095208423> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W3095208423 abstract "Background: Severe alpha-1-antitrypsin deficiency (AATD), phenotype PiZZ is an established risk factor for chronic obstructive pulmonary disease (COPD) and liver disease, but the risk of developing cancer, other than hepatocellular cancer, is unknown. Our aim was to compare the risk of incident cancer in PiZZ individuals with a random sample from the general population with known smoking habits. Methods: The PiZZ individuals (n=1,585) were included in the Swedish National AATD Register. Controls (n=5,999) were selected from the population-based cohorts within the population-based Obstructive Lung disease in Northern Sweden (OLIN) studies. Data on diagnoses of cancer were obtained by nationwide cross-linkage for AATD individuals and controls with the National Cancer Registry and the Swedish National Patient Register (SNPR). All participants were followed from the date of inclusion in the AATD Register or the OLIN studies (baseline) to the date of first cancer during the follow-up, the date of lung transplantation, the date of death, or study end (January 1st, 2015). Results: During median follow-up of 17 years (range 0.2-23 years), 12% (n=185) of the PiZZ individuals and 10% (n=568) of the controls developed cancer. The risk of incident cancer was significantly higher in the general population than in the PiZZ individuals, adjusted hazard ratio (HR) 1.6 (95% CI 1.3-1.9), also in ever-smokers (HR 1.5; 95% CI 1.2-1.8) and never-smokers (HR 1.7; 95% CI 1.3-2.2). Conclusion: PiZZ individuals have a lower risk of developing incident cancer than the general population adjusting for age and sex, both in ever- and never-smokers." @default.
- W3095208423 created "2020-11-09" @default.
- W3095208423 creator A5023838544 @default.
- W3095208423 creator A5038387309 @default.
- W3095208423 creator A5041939325 @default.
- W3095208423 creator A5053310069 @default.
- W3095208423 creator A5059664332 @default.
- W3095208423 creator A5078785073 @default.
- W3095208423 date "2020-09-07" @default.
- W3095208423 modified "2023-09-23" @default.
- W3095208423 title "Risk of cancer in individuals with severe alpha-1-antitrypsin deficiency (PiZZ) compared with the Swedish general population" @default.
- W3095208423 doi "https://doi.org/10.1183/13993003.congress-2020.1124" @default.
- W3095208423 hasPublicationYear "2020" @default.
- W3095208423 type Work @default.
- W3095208423 sameAs 3095208423 @default.
- W3095208423 citedByCount "1" @default.
- W3095208423 countsByYear W30952084232022 @default.
- W3095208423 crossrefType "proceedings-article" @default.
- W3095208423 hasAuthorship W3095208423A5023838544 @default.
- W3095208423 hasAuthorship W3095208423A5038387309 @default.
- W3095208423 hasAuthorship W3095208423A5041939325 @default.
- W3095208423 hasAuthorship W3095208423A5053310069 @default.
- W3095208423 hasAuthorship W3095208423A5059664332 @default.
- W3095208423 hasAuthorship W3095208423A5078785073 @default.
- W3095208423 hasBestOaLocation W30952084231 @default.
- W3095208423 hasConcept C121608353 @default.
- W3095208423 hasConcept C126322002 @default.
- W3095208423 hasConcept C1862650 @default.
- W3095208423 hasConcept C207103383 @default.
- W3095208423 hasConcept C2776256026 @default.
- W3095208423 hasConcept C2776780178 @default.
- W3095208423 hasConcept C2778527826 @default.
- W3095208423 hasConcept C2779134260 @default.
- W3095208423 hasConcept C2780535462 @default.
- W3095208423 hasConcept C2908647359 @default.
- W3095208423 hasConcept C44249647 @default.
- W3095208423 hasConcept C71924100 @default.
- W3095208423 hasConcept C99454951 @default.
- W3095208423 hasConceptScore W3095208423C121608353 @default.
- W3095208423 hasConceptScore W3095208423C126322002 @default.
- W3095208423 hasConceptScore W3095208423C1862650 @default.
- W3095208423 hasConceptScore W3095208423C207103383 @default.
- W3095208423 hasConceptScore W3095208423C2776256026 @default.
- W3095208423 hasConceptScore W3095208423C2776780178 @default.
- W3095208423 hasConceptScore W3095208423C2778527826 @default.
- W3095208423 hasConceptScore W3095208423C2779134260 @default.
- W3095208423 hasConceptScore W3095208423C2780535462 @default.
- W3095208423 hasConceptScore W3095208423C2908647359 @default.
- W3095208423 hasConceptScore W3095208423C44249647 @default.
- W3095208423 hasConceptScore W3095208423C71924100 @default.
- W3095208423 hasConceptScore W3095208423C99454951 @default.
- W3095208423 hasLocation W30952084231 @default.
- W3095208423 hasOpenAccess W3095208423 @default.
- W3095208423 hasPrimaryLocation W30952084231 @default.
- W3095208423 hasRelatedWork W10021799 @default.
- W3095208423 hasRelatedWork W12581806 @default.
- W3095208423 hasRelatedWork W1270249 @default.
- W3095208423 hasRelatedWork W15839946 @default.
- W3095208423 hasRelatedWork W5556885 @default.
- W3095208423 hasRelatedWork W6385940 @default.
- W3095208423 hasRelatedWork W6870675 @default.
- W3095208423 hasRelatedWork W784901 @default.
- W3095208423 hasRelatedWork W8315944 @default.
- W3095208423 hasRelatedWork W8388642 @default.
- W3095208423 isParatext "false" @default.
- W3095208423 isRetracted "false" @default.
- W3095208423 magId "3095208423" @default.
- W3095208423 workType "article" @default.