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• W3095218401 startingPage "2017" @default.
• W3095218401 abstract "Type 2 diabetes mellitus (T2DM) is global health problem. An estimated 425 million people in the world had diabetes in 2017. It is a major cause of morbidity and mortality worldwide. Although, pathogenesis of T2DM and its complications have been focus of medical research for long, much remains to be learned. A better understanding of molecular pathogenesis is essential for more effective preventive and therapeutic interventions. Role of mitochondria in pathogenesis of metabolic problems such as obesity, metabolic syndrome, and T2DM is the focus of many recent research studies. Mitochondrial dysfunction contributes to the oxidative stress and systemic inflammation leading to insulin resistance (IR). Mitochondria are also essential for pancreatic beta cell insulin secretion. Hence, mitochondria are important players in the pathogenesis of T2DM. In this article, pathogenesis of T2DM is examined from a mitochondrial perspective." @default.
• W3095218401 created "2020-11-09" @default.
• W3095218401 creator A5089408804 @default.
• W3095218401 date "2020-11-02" @default.
• W3095218401 modified "2023-10-14" @default.
• W3095218401 title "Role of mitochondria in pathogenesis of type 2 diabetes mellitus" @default.
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• W3095218401 doi "https://doi.org/10.1007/s40200-020-00679-x" @default.
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