Matches in SemOpenAlex for { <https://semopenalex.org/work/W3095286502> ?p ?o ?g. }
- W3095286502 endingPage "198220" @default.
- W3095286502 startingPage "198220" @default.
- W3095286502 abstract "Cyclic GMP-AMP synthase (cGAS) is a main sensor used to detect microbial DNA in the cytoplasm, which subsequently induces the production of interferon (IFN) via the cGAS/STING/IRF3 signaling pathway, leading to an antiviral response. However, some viruses have evolved multiple strategies to escape this process. Pseudorabies virus (PRV) is a double-stranded DNA virus belonging to the Alphaherpesvirinae subfamily, which can cause serious damage to the porcine industry. Many herpesvirus components have been reported to counteract IFN production, whereas little is known of PRV. In the present study, we found that PRV glycoprotein E (gE) was involved in counteracting cGAS/STING-mediated IFN production. Ectopic expression of gE decreased cGAS/STING-mediated IFN-β promoter activity and the level of mRNA expression. Moreover, gE targeted at or downstream of IRF3 was found to inhibit IFN-β production. However, gE did not affect the phosphorylation, dimerization and nuclear translocation of IRF3. Furthermore, gE is located on the nuclear membrane and could subsequently degrade CREB-binding protein (CBP). MG132, a proteasome inhibitor, decreased CBP degradation and restored the IFN-β production induced by gE. Finally, gE-deleted PRV induced a higher level of IFN-β production and reduced CBP degradation compared to wild-type PRV. Together, these results demonstrate that PRV gE can inhibit cGAS/STING-mediated IFN-β production by degrading CBP to interrupt the enhanced assembly of IRF3 and CBP." @default.
- W3095286502 created "2020-11-09" @default.
- W3095286502 creator A5014177100 @default.
- W3095286502 creator A5035298189 @default.
- W3095286502 creator A5048772953 @default.
- W3095286502 creator A5074919815 @default.
- W3095286502 creator A5080864235 @default.
- W3095286502 creator A5090606294 @default.
- W3095286502 date "2021-01-01" @default.
- W3095286502 modified "2023-10-16" @default.
- W3095286502 title "Pseudorabies virus glycoprotein gE suppresses interferon-β production via CREB-binding protein degradation" @default.
- W3095286502 cites W1531950960 @default.
- W3095286502 cites W1537233581 @default.
- W3095286502 cites W1557241876 @default.
- W3095286502 cites W1884928119 @default.
- W3095286502 cites W1898273578 @default.
- W3095286502 cites W1964417328 @default.
- W3095286502 cites W1974759902 @default.
- W3095286502 cites W1994647589 @default.
- W3095286502 cites W2001947268 @default.
- W3095286502 cites W2002411580 @default.
- W3095286502 cites W2009390838 @default.
- W3095286502 cites W2016131266 @default.
- W3095286502 cites W2022002868 @default.
- W3095286502 cites W2036779717 @default.
- W3095286502 cites W2043178000 @default.
- W3095286502 cites W2053476949 @default.
- W3095286502 cites W2055063197 @default.
- W3095286502 cites W2063466305 @default.
- W3095286502 cites W2077291760 @default.
- W3095286502 cites W2093336713 @default.
- W3095286502 cites W2096372976 @default.
- W3095286502 cites W2107024667 @default.
- W3095286502 cites W2110712815 @default.
- W3095286502 cites W2114085082 @default.
- W3095286502 cites W2123645680 @default.
- W3095286502 cites W2124950819 @default.
- W3095286502 cites W2131617804 @default.
- W3095286502 cites W2143475407 @default.
- W3095286502 cites W2147142175 @default.
- W3095286502 cites W2159921922 @default.
- W3095286502 cites W2221608506 @default.
- W3095286502 cites W2233577420 @default.
- W3095286502 cites W2353041718 @default.
- W3095286502 cites W2398563931 @default.
- W3095286502 cites W2405755467 @default.
- W3095286502 cites W2524429440 @default.
- W3095286502 cites W2580172796 @default.
- W3095286502 cites W2580816351 @default.
- W3095286502 cites W2603516643 @default.
- W3095286502 cites W2781731842 @default.
- W3095286502 cites W2804625109 @default.
- W3095286502 cites W2898430747 @default.
- W3095286502 doi "https://doi.org/10.1016/j.virusres.2020.198220" @default.
- W3095286502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33152381" @default.
- W3095286502 hasPublicationYear "2021" @default.
- W3095286502 type Work @default.
- W3095286502 sameAs 3095286502 @default.
- W3095286502 citedByCount "13" @default.
- W3095286502 countsByYear W30952865022021 @default.
- W3095286502 countsByYear W30952865022022 @default.
- W3095286502 countsByYear W30952865022023 @default.
- W3095286502 crossrefType "journal-article" @default.
- W3095286502 hasAuthorship W3095286502A5014177100 @default.
- W3095286502 hasAuthorship W3095286502A5035298189 @default.
- W3095286502 hasAuthorship W3095286502A5048772953 @default.
- W3095286502 hasAuthorship W3095286502A5074919815 @default.
- W3095286502 hasAuthorship W3095286502A5080864235 @default.
- W3095286502 hasAuthorship W3095286502A5090606294 @default.
- W3095286502 hasConcept C104317684 @default.
- W3095286502 hasConcept C153911025 @default.
- W3095286502 hasConcept C159047783 @default.
- W3095286502 hasConcept C181199279 @default.
- W3095286502 hasConcept C2522874641 @default.
- W3095286502 hasConcept C2776178377 @default.
- W3095286502 hasConcept C2777349159 @default.
- W3095286502 hasConcept C2780209191 @default.
- W3095286502 hasConcept C2781092067 @default.
- W3095286502 hasConcept C55493867 @default.
- W3095286502 hasConcept C86339819 @default.
- W3095286502 hasConcept C86803240 @default.
- W3095286502 hasConcept C98539663 @default.
- W3095286502 hasConceptScore W3095286502C104317684 @default.
- W3095286502 hasConceptScore W3095286502C153911025 @default.
- W3095286502 hasConceptScore W3095286502C159047783 @default.
- W3095286502 hasConceptScore W3095286502C181199279 @default.
- W3095286502 hasConceptScore W3095286502C2522874641 @default.
- W3095286502 hasConceptScore W3095286502C2776178377 @default.
- W3095286502 hasConceptScore W3095286502C2777349159 @default.
- W3095286502 hasConceptScore W3095286502C2780209191 @default.
- W3095286502 hasConceptScore W3095286502C2781092067 @default.
- W3095286502 hasConceptScore W3095286502C55493867 @default.
- W3095286502 hasConceptScore W3095286502C86339819 @default.
- W3095286502 hasConceptScore W3095286502C86803240 @default.
- W3095286502 hasConceptScore W3095286502C98539663 @default.
- W3095286502 hasFunder F4320327518 @default.
- W3095286502 hasFunder F4320335440 @default.
- W3095286502 hasFunder F4320335787 @default.