FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3095303863> ?p ?o ?g. }

• W3095303863 abstract "Polysaccharide A (PSA), a capsular carbohydrate from the commensal gut bacteria Bacteroides fragilis, has been shown to possess both potent T cell-dependent pro- and anti-inflammatory properties. PSA is able to induce abscess and adhesion formation in sepsis models, but can also inhibit asthma, inflammatory bowel disease (IBD) and experimental autoimmune encephalomyelitis (EAE) through MHCII-dependent activation of CD4+ T cells. Yet, despite decades of study, the ability of PSA to balance both these pro- and anti-inflammatory responses remains poorly understood. Here, we utilized an unbiased systems immunology approach consisting of RNAseq transcriptomics, high-throughput flow cytometry, and Luminex analysis to characterize the full impact of PSA-mediated stimulation of CD4+ T cells. We found that exposure to PSA resulted in the upregulation and secretion of IFNγ, TNFα, IL-6, and CXCL10, consistent with an interferon responsive gene (IRG) signature. Importantly, PSA stimulation also led to expression of immune checkpoint markers Lag3, Tim3, and, especially, PD1, which were also enriched and sustained in the gut associated lymphoid tissue of PSA-exposed mice. Taken together, PSA responding cells display an unusual mixture of pro-inflammatory cytokines and anti-inflammatory surface receptors, consistent with the ability to both cause and inhibit inflammatory disease." @default.
• W3095303863 created "2020-11-09" @default.
• W3095303863 creator A5002726217 @default.
• W3095303863 creator A5040475295 @default.
• W3095303863 creator A5046791728 @default.
• W3095303863 creator A5088355600 @default.
• W3095303863 date "2020-10-26" @default.
• W3095303863 modified "2023-10-14" @default.
• W3095303863 title "Characterization of Polysaccharide A Response Reveals Interferon Responsive Gene Signature and Immunomodulatory Marker Expression" @default.
• W3095303863 cites W1499206957 @default.
• W3095303863 cites W1519270060 @default.
• W3095303863 cites W1560531583 @default.
• W3095303863 cites W1973268693 @default.
• W3095303863 cites W1973309978 @default.
• W3095303863 cites W1975469885 @default.
• W3095303863 cites W1988183869 @default.
• W3095303863 cites W1996454579 @default.
• W3095303863 cites W1998995307 @default.
• W3095303863 cites W2003988648 @default.
• W3095303863 cites W2010457001 @default.
• W3095303863 cites W2017712207 @default.
• W3095303863 cites W2026779719 @default.
• W3095303863 cites W2033981815 @default.
• W3095303863 cites W2040331558 @default.
• W3095303863 cites W2041589578 @default.
• W3095303863 cites W2044999271 @default.
• W3095303863 cites W2057454595 @default.
• W3095303863 cites W2063262427 @default.
• W3095303863 cites W2072417345 @default.
• W3095303863 cites W2075325752 @default.
• W3095303863 cites W2083215278 @default.
• W3095303863 cites W2088534886 @default.
• W3095303863 cites W2103885096 @default.
• W3095303863 cites W2106829739 @default.
• W3095303863 cites W2107842454 @default.
• W3095303863 cites W2112948254 @default.
• W3095303863 cites W2118471749 @default.
• W3095303863 cites W2122751127 @default.
• W3095303863 cites W2130410032 @default.
• W3095303863 cites W2133169528 @default.
• W3095303863 cites W2133402546 @default.
• W3095303863 cites W2138727782 @default.
• W3095303863 cites W2139591061 @default.
• W3095303863 cites W2149326135 @default.
• W3095303863 cites W2156592449 @default.
• W3095303863 cites W2167017590 @default.
• W3095303863 cites W2167612055 @default.
• W3095303863 cites W2403400382 @default.
• W3095303863 cites W2472593842 @default.
• W3095303863 cites W2595926651 @default.
• W3095303863 cites W2765864836 @default.
• W3095303863 cites W2784466101 @default.
• W3095303863 cites W2793484970 @default.
• W3095303863 cites W2922489539 @default.
• W3095303863 cites W2945318499 @default.
• W3095303863 cites W2945358523 @default.
• W3095303863 cites W2959390992 @default.
• W3095303863 doi "https://doi.org/10.3389/fimmu.2020.556813" @default.
• W3095303863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7649347" @default.
• W3095303863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33193325" @default.
• W3095303863 hasPublicationYear "2020" @default.
• W3095303863 type Work @default.
• W3095303863 sameAs 3095303863 @default.
• W3095303863 citedByCount "16" @default.
• W3095303863 countsByYear W30953038632021 @default.
• W3095303863 countsByYear W30953038632022 @default.
• W3095303863 countsByYear W30953038632023 @default.
• W3095303863 crossrefType "journal-article" @default.
• W3095303863 hasAuthorship W3095303863A5002726217 @default.
• W3095303863 hasAuthorship W3095303863A5040475295 @default.
• W3095303863 hasAuthorship W3095303863A5046791728 @default.
• W3095303863 hasAuthorship W3095303863A5088355600 @default.
• W3095303863 hasBestOaLocation W30953038631 @default.
• W3095303863 hasConcept C100817775 @default.
• W3095303863 hasConcept C104317684 @default.
• W3095303863 hasConcept C150194340 @default.
• W3095303863 hasConcept C203014093 @default.
• W3095303863 hasConcept C2524010 @default.
• W3095303863 hasConcept C2776178377 @default.
• W3095303863 hasConcept C2779696439 @default.
• W3095303863 hasConcept C2779733811 @default.
• W3095303863 hasConcept C33923547 @default.
• W3095303863 hasConcept C54355233 @default.
• W3095303863 hasConcept C55493867 @default.
• W3095303863 hasConcept C86803240 @default.
• W3095303863 hasConceptScore W3095303863C100817775 @default.
• W3095303863 hasConceptScore W3095303863C104317684 @default.
• W3095303863 hasConceptScore W3095303863C150194340 @default.
• W3095303863 hasConceptScore W3095303863C203014093 @default.
• W3095303863 hasConceptScore W3095303863C2524010 @default.
• W3095303863 hasConceptScore W3095303863C2776178377 @default.
• W3095303863 hasConceptScore W3095303863C2779696439 @default.
• W3095303863 hasConceptScore W3095303863C2779733811 @default.
• W3095303863 hasConceptScore W3095303863C33923547 @default.
• W3095303863 hasConceptScore W3095303863C54355233 @default.
• W3095303863 hasConceptScore W3095303863C55493867 @default.
• W3095303863 hasConceptScore W3095303863C86803240 @default.
• W3095303863 hasFunder F4320306257 @default.
• W3095303863 hasFunder F4320337351 @default.
• W3095303863 hasFunder F4320337354 @default.

• next