FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3095367035> ?p ?o ?g. }

• W3095367035 endingPage "153" @default.
• W3095367035 startingPage "142" @default.
• W3095367035 abstract "Circulating levels of endothelial miR-150 are reduced in pulmonary arterial hypertension (PAH) and act as an independent predictor of patient survival, but links between endothelial miR-150 and vascular dysfunction are not well understood. We studied the effects of endothelial miR-150 supplementation and inhibition in PAH mice and cells from patients with idiopathic PAH. The role of selected mediators of miR-150 identified by RNA sequencing was evaluated in vitro and in vivo. Endothelium-targeted miR-150 delivery prevented the disease in Sugen/hypoxia mice, while endothelial knockdown of miR-150 had adverse effects. miR-150 target genes revealed significant associations with PAH pathways, including proliferation, inflammation, and phospholipid signaling, with PTEN-like mitochondrial phosphatase (PTPMT1) most markedly altered. PTPMT1 reduced inflammation and apoptosis and improved mitochondrial function in human pulmonary endothelial cells and blood-derived endothelial colony-forming cells from idiopathic PAH. Beneficial effects of miR-150 in vitro and in vivo were linked with PTPMT1-dependent biosynthesis of mitochondrial phospholipid cardiolipin and reduced expression of pro-apoptotic, pro-inflammatory, and pro-fibrotic genes, including c-MYB, NOTCH3, transforming growth factor β (TGF-β), and Col1a1. In conclusion, we are the first to show that miR-150 supplementation attenuates pulmonary endothelial damage induced by vascular stresses and may be considered as a potential therapeutic strategy in PAH." @default.
• W3095367035 created "2020-11-09" @default.
• W3095367035 creator A5013255443 @default.
• W3095367035 creator A5039695021 @default.
• W3095367035 creator A5051310973 @default.
• W3095367035 creator A5056418668 @default.
• W3095367035 creator A5068191376 @default.
• W3095367035 creator A5069533118 @default.
• W3095367035 creator A5072633308 @default.
• W3095367035 creator A5073503336 @default.
• W3095367035 creator A5074112347 @default.
• W3095367035 creator A5074722057 @default.
• W3095367035 date "2021-03-01" @default.
• W3095367035 modified "2023-10-16" @default.
• W3095367035 title "miR-150-PTPMT1-cardiolipin signaling in pulmonary arterial hypertension" @default.
• W3095367035 cites W1590964273 @default.
• W3095367035 cites W1960895270 @default.
• W3095367035 cites W1973096186 @default.
• W3095367035 cites W1991312642 @default.
• W3095367035 cites W1999388852 @default.
• W3095367035 cites W2011477996 @default.
• W3095367035 cites W2014346055 @default.
• W3095367035 cites W2024102779 @default.
• W3095367035 cites W2028813118 @default.
• W3095367035 cites W2029289451 @default.
• W3095367035 cites W2031921417 @default.
• W3095367035 cites W2037731687 @default.
• W3095367035 cites W2049604140 @default.
• W3095367035 cites W2052425671 @default.
• W3095367035 cites W2052801373 @default.
• W3095367035 cites W2071319446 @default.
• W3095367035 cites W2086789976 @default.
• W3095367035 cites W2090455548 @default.
• W3095367035 cites W2094253263 @default.
• W3095367035 cites W2099728493 @default.
• W3095367035 cites W2122454281 @default.
• W3095367035 cites W2125618584 @default.
• W3095367035 cites W2127643187 @default.
• W3095367035 cites W2128213692 @default.
• W3095367035 cites W2155754747 @default.
• W3095367035 cites W2158749167 @default.
• W3095367035 cites W2161561494 @default.
• W3095367035 cites W2187976253 @default.
• W3095367035 cites W2267638375 @default.
• W3095367035 cites W2398014928 @default.
• W3095367035 cites W2587119682 @default.
• W3095367035 cites W2591947019 @default.
• W3095367035 cites W2617303046 @default.
• W3095367035 cites W2736256474 @default.
• W3095367035 cites W2757651286 @default.
• W3095367035 cites W2777517924 @default.
• W3095367035 cites W2886083365 @default.
• W3095367035 cites W2898592159 @default.
• W3095367035 cites W2901522911 @default.
• W3095367035 cites W2946714259 @default.
• W3095367035 cites W3009377098 @default.
• W3095367035 cites W3012114822 @default.
• W3095367035 doi "https://doi.org/10.1016/j.omtn.2020.10.042" @default.
• W3095367035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7733016" @default.
• W3095367035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33335799" @default.
• W3095367035 hasPublicationYear "2021" @default.
• W3095367035 type Work @default.
• W3095367035 sameAs 3095367035 @default.
• W3095367035 citedByCount "14" @default.
• W3095367035 countsByYear W30953670352021 @default.
• W3095367035 countsByYear W30953670352022 @default.
• W3095367035 countsByYear W30953670352023 @default.
• W3095367035 crossrefType "journal-article" @default.
• W3095367035 hasAuthorship W3095367035A5013255443 @default.
• W3095367035 hasAuthorship W3095367035A5039695021 @default.
• W3095367035 hasAuthorship W3095367035A5051310973 @default.
• W3095367035 hasAuthorship W3095367035A5056418668 @default.
• W3095367035 hasAuthorship W3095367035A5068191376 @default.
• W3095367035 hasAuthorship W3095367035A5069533118 @default.
• W3095367035 hasAuthorship W3095367035A5072633308 @default.
• W3095367035 hasAuthorship W3095367035A5073503336 @default.
• W3095367035 hasAuthorship W3095367035A5074112347 @default.
• W3095367035 hasAuthorship W3095367035A5074722057 @default.
• W3095367035 hasBestOaLocation W30953670351 @default.
• W3095367035 hasConcept C126322002 @default.
• W3095367035 hasConcept C134018914 @default.
• W3095367035 hasConcept C146285616 @default.
• W3095367035 hasConcept C150903083 @default.
• W3095367035 hasConcept C15215337 @default.
• W3095367035 hasConcept C167734588 @default.
• W3095367035 hasConcept C173396325 @default.
• W3095367035 hasConcept C178790620 @default.
• W3095367035 hasConcept C185592680 @default.
• W3095367035 hasConcept C190283241 @default.
• W3095367035 hasConcept C203014093 @default.
• W3095367035 hasConcept C207001950 @default.
• W3095367035 hasConcept C2776914184 @default.
• W3095367035 hasConcept C2776992346 @default.
• W3095367035 hasConcept C2777025900 @default.
• W3095367035 hasConcept C2778918659 @default.
• W3095367035 hasConcept C2780930700 @default.
• W3095367035 hasConcept C2780972559 @default.
• W3095367035 hasConcept C2781302388 @default.

• next