Matches in SemOpenAlex for { <https://semopenalex.org/work/W3095397248> ?p ?o ?g. }
- W3095397248 abstract "Abstract Background Transposable elements (TEs) are an almost universal constituent of eukaryotic genomes. In animals, Piwi-interacting small RNAs (piRNAs) and repressive chromatin often play crucial roles in preventing TE transcription and thus restricting TE activity. Nevertheless, TE content varies widely across eukaryotes and the dynamics of TE activity and TE silencing across evolutionary time is poorly understood. Results Here, we used experimentally evolved populations of C. elegans to study the dynamics of TE expression over 409 generations. The experimental populations were evolved at population sizes of 1, 10 and 100 individuals to manipulate the efficiency of natural selection versus genetic drift. We demonstrate increased TE expression relative to the ancestral population, with the largest increases occurring in the smallest populations. We show that the transcriptional activation of TEs within active regions of the genome is associated with failure of piRNA-mediated silencing, whilst desilenced TEs in repressed chromatin domains retain small RNAs. Additionally, we find that the sequence context of the surrounding region influences the propensity of TEs to lose silencing through failure of small RNA-mediated silencing. Conclusions Our results show that natural selection in C. elegans is responsible for maintaining low levels of TE expression, and provide new insights into the epigenomic features responsible." @default.
- W3095397248 created "2020-11-09" @default.
- W3095397248 creator A5000551479 @default.
- W3095397248 creator A5013637327 @default.
- W3095397248 creator A5014495066 @default.
- W3095397248 creator A5021225000 @default.
- W3095397248 creator A5042677899 @default.
- W3095397248 creator A5065228994 @default.
- W3095397248 creator A5083945868 @default.
- W3095397248 date "2020-11-06" @default.
- W3095397248 modified "2023-10-10" @default.
- W3095397248 title "Long-term experimental evolution reveals purifying selection on piRNA-mediated control of transposable element expression" @default.
- W3095397248 cites W1528776873 @default.
- W3095397248 cites W1544431211 @default.
- W3095397248 cites W1816943760 @default.
- W3095397248 cites W1861196385 @default.
- W3095397248 cites W1885681284 @default.
- W3095397248 cites W1930635754 @default.
- W3095397248 cites W1932581232 @default.
- W3095397248 cites W1963896667 @default.
- W3095397248 cites W1965717293 @default.
- W3095397248 cites W1976342457 @default.
- W3095397248 cites W1987908533 @default.
- W3095397248 cites W1994473944 @default.
- W3095397248 cites W1995048848 @default.
- W3095397248 cites W2006801473 @default.
- W3095397248 cites W2010596106 @default.
- W3095397248 cites W2011812857 @default.
- W3095397248 cites W2014938755 @default.
- W3095397248 cites W2015423672 @default.
- W3095397248 cites W2026952154 @default.
- W3095397248 cites W2029846963 @default.
- W3095397248 cites W2032640887 @default.
- W3095397248 cites W2034206562 @default.
- W3095397248 cites W2037430996 @default.
- W3095397248 cites W2037594820 @default.
- W3095397248 cites W2057558367 @default.
- W3095397248 cites W2061710204 @default.
- W3095397248 cites W2062429478 @default.
- W3095397248 cites W2081719540 @default.
- W3095397248 cites W2082578963 @default.
- W3095397248 cites W2085361724 @default.
- W3095397248 cites W2088014737 @default.
- W3095397248 cites W2089661916 @default.
- W3095397248 cites W2090853729 @default.
- W3095397248 cites W2097065948 @default.
- W3095397248 cites W2100619913 @default.
- W3095397248 cites W2100874076 @default.
- W3095397248 cites W2101921189 @default.
- W3095397248 cites W2111217101 @default.
- W3095397248 cites W2118076127 @default.
- W3095397248 cites W2118420574 @default.
- W3095397248 cites W2122984483 @default.
- W3095397248 cites W2128023973 @default.
- W3095397248 cites W2138910750 @default.
- W3095397248 cites W2141458291 @default.
- W3095397248 cites W2142603647 @default.
- W3095397248 cites W2148105495 @default.
- W3095397248 cites W2154222068 @default.
- W3095397248 cites W2155496026 @default.
- W3095397248 cites W2161538889 @default.
- W3095397248 cites W2169179032 @default.
- W3095397248 cites W2437865583 @default.
- W3095397248 cites W2469085018 @default.
- W3095397248 cites W2532937293 @default.
- W3095397248 cites W2556763090 @default.
- W3095397248 cites W2593381894 @default.
- W3095397248 cites W2593551397 @default.
- W3095397248 cites W2594086611 @default.
- W3095397248 cites W2613576825 @default.
- W3095397248 cites W2749620102 @default.
- W3095397248 cites W2755067651 @default.
- W3095397248 cites W2767126626 @default.
- W3095397248 cites W2786551169 @default.
- W3095397248 cites W2788865254 @default.
- W3095397248 cites W2791231555 @default.
- W3095397248 cites W2809594440 @default.
- W3095397248 cites W2810139475 @default.
- W3095397248 cites W2901793276 @default.
- W3095397248 cites W2903093521 @default.
- W3095397248 cites W2913702142 @default.
- W3095397248 cites W2949613230 @default.
- W3095397248 cites W2950147181 @default.
- W3095397248 cites W2972229826 @default.
- W3095397248 cites W2994748282 @default.
- W3095397248 cites W2997987157 @default.
- W3095397248 cites W3081887529 @default.
- W3095397248 cites W4230501579 @default.
- W3095397248 cites W4243533475 @default.
- W3095397248 doi "https://doi.org/10.1186/s12915-020-00897-y" @default.
- W3095397248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7646084" @default.
- W3095397248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33158445" @default.
- W3095397248 hasPublicationYear "2020" @default.
- W3095397248 type Work @default.
- W3095397248 sameAs 3095397248 @default.
- W3095397248 citedByCount "7" @default.
- W3095397248 countsByYear W30953972482021 @default.
- W3095397248 countsByYear W30953972482022 @default.
- W3095397248 crossrefType "journal-article" @default.
- W3095397248 hasAuthorship W3095397248A5000551479 @default.