Matches in SemOpenAlex for { <https://semopenalex.org/work/W3095512537> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3095512537 endingPage "42" @default.
- W3095512537 startingPage "29" @default.
- W3095512537 abstract "Three simple, rapid, inexpensive, precise and accurate UV spectrophotometric methods have been developed for simultaneous estimation of Brexpiprazole and Sertraline. Method A was simultaneous equation method (vireo’s method) which applies measurement of absorptivity at two wavelength 325 nm, (λmax of Brexpiprazole) and 274 nm, (λmax of Sertraline) in zero order spectra. The concentration calculated from the derived equations. Method B was Absorption Ratio Method (Q-ratio) which applies measurement of Absorptivity at two wavelength 275.88 nm (Iso-absorptive point) of both drugs and 325 nm (λmax of Brexpiprazole) in zero order spectra. Method C was based on zero crossing Second derivative (D2) spectrophotometry where Brexpiprazole showed zero crossing point at 268 nm and Sertraline showed zero crossing point at 280 nm. Linearity for Brexpiprazole was between 1-7 mcg/ml and Sertraline was between 20-140 mcg/ml. Accuracy of all the above methods was determined by recovery studies and % recovery was estimated between 99.01 to 101.80%. Intraday and Inter day precision was checked for all methods and mean % RSD was found to be less than 2. These methods were successfully applied for estimation of Brexpiprazole and Sertraline in Laboratory sample. Four chemometrics methods were also applied to simultaneous determination of Brexpiprazole and Sertraline in simulated mixture. Classical least- square(CLS), inverse least-square(ILS), principal component regression(PCR) and partial least-square(PLS) methods do not need any priori graphical treatment of the overlapping spectra of two drugs in a mixture. For all chemometrics calibration a concentration set of the random mixture consisting of the two drugs in methanol was prepared. The absorbance data in the UV spectra were measured for the 41 wavelength points (from 200 to 400 nm) in the spectral region 200-400 nm considering the intervals of Δλ=5 nm. It is claimed that these new chemometrics-assisted spectrophotometric methods are inexpensive, rapid, and simple and can be trustfully carried out in quality control laboratories. Statistical analysis was done to compare all the three developed spectroscopic methods. Brexpiprazole there was a statistically significant difference as P-value for Brexpiprazole was less than α=0.05 and observed F value was higher than Fcritical values. Therefore, Post-hoc analysis using multiple comparisons by Tukey‘s test was performed for Brexpiprazole. This revealed that Method A (Simultaneous equation method [vierdot‘s method]) was significantly different from other methods." @default.
- W3095512537 created "2020-11-09" @default.
- W3095512537 creator A5033522429 @default.
- W3095512537 creator A5087486634 @default.
- W3095512537 date "2020-01-01" @default.
- W3095512537 modified "2023-09-23" @default.
- W3095512537 title "Novel UV spectrophotometric & chemometrics assisted spectrophotometric methods for simultaneous estimation of Brexpiprazole and Sertraline: A statistical analysis" @default.
- W3095512537 hasPublicationYear "2020" @default.
- W3095512537 type Work @default.
- W3095512537 sameAs 3095512537 @default.
- W3095512537 citedByCount "0" @default.
- W3095512537 crossrefType "journal-article" @default.
- W3095512537 hasAuthorship W3095512537A5033522429 @default.
- W3095512537 hasAuthorship W3095512537A5087486634 @default.
- W3095512537 hasConcept C105795698 @default.
- W3095512537 hasConcept C113196181 @default.
- W3095512537 hasConcept C120665830 @default.
- W3095512537 hasConcept C121332964 @default.
- W3095512537 hasConcept C151304367 @default.
- W3095512537 hasConcept C185592680 @default.
- W3095512537 hasConcept C22354355 @default.
- W3095512537 hasConcept C2780343419 @default.
- W3095512537 hasConcept C33923547 @default.
- W3095512537 hasConcept C43617362 @default.
- W3095512537 hasConcept C48921125 @default.
- W3095512537 hasConcept C74887250 @default.
- W3095512537 hasConcept C76046532 @default.
- W3095512537 hasConceptScore W3095512537C105795698 @default.
- W3095512537 hasConceptScore W3095512537C113196181 @default.
- W3095512537 hasConceptScore W3095512537C120665830 @default.
- W3095512537 hasConceptScore W3095512537C121332964 @default.
- W3095512537 hasConceptScore W3095512537C151304367 @default.
- W3095512537 hasConceptScore W3095512537C185592680 @default.
- W3095512537 hasConceptScore W3095512537C22354355 @default.
- W3095512537 hasConceptScore W3095512537C2780343419 @default.
- W3095512537 hasConceptScore W3095512537C33923547 @default.
- W3095512537 hasConceptScore W3095512537C43617362 @default.
- W3095512537 hasConceptScore W3095512537C48921125 @default.
- W3095512537 hasConceptScore W3095512537C74887250 @default.
- W3095512537 hasConceptScore W3095512537C76046532 @default.
- W3095512537 hasIssue "8" @default.
- W3095512537 hasLocation W30955125371 @default.
- W3095512537 hasOpenAccess W3095512537 @default.
- W3095512537 hasPrimaryLocation W30955125371 @default.
- W3095512537 hasRelatedWork W1987332049 @default.
- W3095512537 hasRelatedWork W2047980384 @default.
- W3095512537 hasRelatedWork W2123501281 @default.
- W3095512537 hasRelatedWork W2148494930 @default.
- W3095512537 hasRelatedWork W2183117972 @default.
- W3095512537 hasRelatedWork W2185497925 @default.
- W3095512537 hasRelatedWork W2189465857 @default.
- W3095512537 hasRelatedWork W2578626744 @default.
- W3095512537 hasRelatedWork W2607456942 @default.
- W3095512537 hasRelatedWork W2775296534 @default.
- W3095512537 hasRelatedWork W2788430347 @default.
- W3095512537 hasRelatedWork W2971466212 @default.
- W3095512537 hasRelatedWork W2973573345 @default.
- W3095512537 hasRelatedWork W3200028601 @default.
- W3095512537 hasRelatedWork W2181965967 @default.
- W3095512537 hasRelatedWork W2183477257 @default.
- W3095512537 hasRelatedWork W2185142324 @default.
- W3095512537 hasRelatedWork W2186728416 @default.
- W3095512537 hasRelatedWork W2188966420 @default.
- W3095512537 hasRelatedWork W2560041681 @default.
- W3095512537 hasVolume "9" @default.
- W3095512537 isParatext "false" @default.
- W3095512537 isRetracted "false" @default.
- W3095512537 magId "3095512537" @default.
- W3095512537 workType "article" @default.