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- W3095576251 abstract "ABSTRACT The main function of blood platelets is to ensure hemostasis and prevent hemorrhages. The 1011 platelets needed daily are produced in a well-orchestrated process. However, this process is not yet fully understood and in vitro platelet production is still inefficient. Platelets are produced in the bone marrow by megakaryocytes, highly specialized precursor cells that extend cytoplasmic projections called proplatelets (PPTs) through the endothelial barrier of sinusoid vessels. In this Cell Science at a Glance article and the accompanying poster we discuss the mechanisms and pathways involved in megakaryopoiesis and platelet formation processes. We especially address the – still underestimated – role of the microenvironment of the bone marrow, and present recent findings on how PPT extension in vivo differs from that in vitro and entails different mechanisms. Finally, we recapitulate old but recently revisited evidence that – although bone marrow does produce megakaryocytes and PPTs – remodeling and the release of bona fide platelets, mainly occur in the downstream microcirculation." @default.
- W3095576251 created "2020-11-09" @default.
- W3095576251 creator A5004016667 @default.
- W3095576251 creator A5018452732 @default.
- W3095576251 creator A5025490736 @default.
- W3095576251 creator A5038703407 @default.
- W3095576251 creator A5067713940 @default.
- W3095576251 date "2020-10-15" @default.
- W3095576251 modified "2023-10-06" @default.
- W3095576251 title "Blood platelet formation at a glance" @default.
- W3095576251 cites W107472485 @default.
- W3095576251 cites W116948353 @default.
- W3095576251 cites W1492619899 @default.
- W3095576251 cites W1516607803 @default.
- W3095576251 cites W1565725475 @default.
- W3095576251 cites W1787222452 @default.
- W3095576251 cites W1906647772 @default.
- W3095576251 cites W1967083571 @default.
- W3095576251 cites W1967124917 @default.
- W3095576251 cites W1967467568 @default.
- W3095576251 cites W196867602 @default.
- W3095576251 cites W1969318465 @default.
- W3095576251 cites W1982179481 @default.
- W3095576251 cites W1983779583 @default.
- W3095576251 cites W1989737463 @default.
- W3095576251 cites W199516120 @default.
- W3095576251 cites W2000404669 @default.
- W3095576251 cites W2007590156 @default.
- W3095576251 cites W2019698339 @default.
- W3095576251 cites W2020496842 @default.
- W3095576251 cites W2023957032 @default.
- W3095576251 cites W2027582961 @default.
- W3095576251 cites W2030309930 @default.
- W3095576251 cites W2039803934 @default.
- W3095576251 cites W2041629873 @default.
- W3095576251 cites W2044089028 @default.
- W3095576251 cites W2048670380 @default.
- W3095576251 cites W2049766622 @default.
- W3095576251 cites W2051321857 @default.
- W3095576251 cites W2052039232 @default.
- W3095576251 cites W2054475676 @default.
- W3095576251 cites W2055045637 @default.
- W3095576251 cites W2056868742 @default.
- W3095576251 cites W2060891467 @default.
- W3095576251 cites W2064049463 @default.
- W3095576251 cites W2070058005 @default.
- W3095576251 cites W2071050246 @default.
- W3095576251 cites W2074435893 @default.
- W3095576251 cites W2075251539 @default.
- W3095576251 cites W2075376229 @default.
- W3095576251 cites W2077428330 @default.
- W3095576251 cites W2079552505 @default.
- W3095576251 cites W2081714880 @default.
- W3095576251 cites W2085199501 @default.
- W3095576251 cites W2085626514 @default.
- W3095576251 cites W2087569857 @default.
- W3095576251 cites W2088021325 @default.
- W3095576251 cites W2088178950 @default.
- W3095576251 cites W2090786449 @default.
- W3095576251 cites W2092616341 @default.
- W3095576251 cites W2093681208 @default.
- W3095576251 cites W2095106591 @default.
- W3095576251 cites W2096364098 @default.
- W3095576251 cites W2096474189 @default.
- W3095576251 cites W2102860458 @default.
- W3095576251 cites W2103532641 @default.
- W3095576251 cites W2111383481 @default.
- W3095576251 cites W2114591684 @default.
- W3095576251 cites W2116972703 @default.
- W3095576251 cites W2118158295 @default.
- W3095576251 cites W2124525107 @default.
- W3095576251 cites W2124554598 @default.
- W3095576251 cites W2132274201 @default.
- W3095576251 cites W2153457817 @default.
- W3095576251 cites W2153503145 @default.
- W3095576251 cites W2156854229 @default.
- W3095576251 cites W2158570224 @default.
- W3095576251 cites W2313461652 @default.
- W3095576251 cites W2317915666 @default.
- W3095576251 cites W2318106569 @default.
- W3095576251 cites W2332717524 @default.
- W3095576251 cites W2342685194 @default.
- W3095576251 cites W2390575125 @default.
- W3095576251 cites W2400198807 @default.
- W3095576251 cites W2485927573 @default.
- W3095576251 cites W2499620398 @default.
- W3095576251 cites W2581362460 @default.
- W3095576251 cites W2600669583 @default.
- W3095576251 cites W2606672799 @default.
- W3095576251 cites W2624099829 @default.
- W3095576251 cites W2624967769 @default.
- W3095576251 cites W26912359 @default.
- W3095576251 cites W2736836364 @default.
- W3095576251 cites W2741821425 @default.
- W3095576251 cites W2757274660 @default.
- W3095576251 cites W2767020540 @default.
- W3095576251 cites W2773632105 @default.
- W3095576251 cites W2781886817 @default.
- W3095576251 cites W2782225074 @default.
- W3095576251 cites W2788865076 @default.