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• W3095706265 abstract "To provide updates on terminology, epidemiology, diagnosis, and treatment of combined hepatocellular-cholangiocarcinoma (cHCC-CCA).cHCC-CCAs are tumors that in the same nodule contain a variable degree of HCC and CCA components with a transition zone. cHCC-CCAs develop in cirrhotic and non-cirrhotic livers like and is associated with poor outcomes. Mutations in TP53, TERT promoter, and ARID1A are the most common genetic aberrations in cHCC-CCA. Fusion gene PTMS-AP1G1 is unique for cHCC-CCA. A biopsy is required for diagnosis. Surgical resection remains treatment of choice, while liver transplantation for early cHCC-CCA is associated with favorable outcomes. Gemcitabine-based therapy shows benefits for advanced cHCC-CCA.cHCC-CCAs are a heterogeneous group of primary liver cancers with unique biological behavior. Multicenter studies are required for a molecular analysis to inform novel therapeutic approaches, and understand epidemiology and benefits of liver transplantation, liver-directed and targeted therapies for this rare aggressive cancer." @default.
• W3095706265 created "2020-11-09" @default.
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• W3095706265 date "2020-10-31" @default.
• W3095706265 modified "2023-10-10" @default.
• W3095706265 title "A Contemporary Approach to Diagnosis and Treatment of Combined Hepatocellular-Cholangiocarcinoma" @default.
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• W3095706265 doi "https://doi.org/10.1007/s11901-020-00556-4" @default.
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