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• W3095824494 startingPage "2996" @default.
• W3095824494 abstract "The oncosuppressor protein p53 plays a major role in transcriptionally controlling the expression of a number of genes, which in turn regulates many functions in response to DNA damage, oncogene triggering, oxidative, and additional cell stresses. A developing area of interest in p53 is the studies related to its cytoplasmic function(s). Many investigations revealed the significant role of p53 in the cytoplasm, acting in a transcriptional-independent manner in important processes related to cell homeostasis such as; apoptosis, autophagy, metabolism control, drug, and oxidative stress response. The studies on cytoplasmic p53 have shown intricate mechanisms by which posttranslational modifications allow p53 to perform its cytoplasmic functions. A number of ubiquitins, deubiquitins, and small ubiquitin-like proteins, have a pivotal role in controlling cytoplasmic stability and localization. Recently, HOPS/TMUB1 a novel small ubiquitin-like protein has been described as a vital molecule stabilizing p53 half-life, directing it to the mitochondria and favoring p53-mediated apoptosis. Furthermore, HOPS/TMUB1 competing with importin-α lessens p53 nuclear localization, thereby increasing cytoplasmic concentration. HOPS/TMUB1 as p53 modifiers could be attractive candidates to elucidate apoptosis or other important transcriptional-independent functions which are key in cancer research in order to develop new therapeutic approaches." @default.
• W3095824494 created "2020-11-09" @default.
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• W3095824494 date "2020-10-28" @default.
• W3095824494 modified "2023-09-25" @default.
• W3095824494 title "HOPS and p53: thick as thieves in life and death" @default.
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• W3095824494 doi "https://doi.org/10.1080/15384101.2020.1838772" @default.
• W3095824494 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7714459" @default.
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