FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3095865997> ?p ?o ?g. }

• W3095865997 endingPage "63" @default.
• W3095865997 startingPage "54" @default.
• W3095865997 abstract "Mouse models that replicate facets of human neurological diseases are often used at the pre-clinical stage to better understand the underlying mechanisms of a disease and test the target engagement of potential therapeutic interventions. We recently characterized a mouse model of childhood-onset parkinsonism-dystonia, a disease caused by a homozygous loss-of-function mutation in the SLC39A14 gene. The disease manifests itself phenotypically by impairments in locomotor behaviour and postural abnormalities. Our initial characterization of the model revealed that the Slc39a14-/- mice showed altered Mn homeostasis and compromised locomotor performance in vertical pole-descending, horizontal beam-traversing, and rotarod tests (Jenkitkasemwong et al., 2018). However, some of the mice also displayed torticollis and Straub tail. In this study, we investigated whether these postural abnormalities affected the performance in the above motility tests and consequently, biased and compromised the external validity of reported abnormal locomotor profiles. Our analyses showed that the Slc39a14-/- mice displaying torticollis and/or Straub tail had tests scores comparable to scores of their counterparts that never displayed these postural abnormalities. The z-score general index of performance revealed that the Slc39a14-/- model presents a complex pathological motor phenotype relevant to the complexity of phenotypes identified in childhood-onset parkinsonism-dystonia." @default.
• W3095865997 created "2020-11-09" @default.
• W3095865997 creator A5054504895 @default.
• W3095865997 creator A5088875879 @default.
• W3095865997 date "2021-01-01" @default.
• W3095865997 modified "2023-09-27" @default.
• W3095865997 title "Phenotypic evaluation of a childhood-onset parkinsonism-dystonia mouse model with inherent postural abnormalities" @default.
• W3095865997 cites W1494091480 @default.
• W3095865997 cites W1835461481 @default.
• W3095865997 cites W1966598943 @default.
• W3095865997 cites W1969039742 @default.
• W3095865997 cites W1969826686 @default.
• W3095865997 cites W1970168744 @default.
• W3095865997 cites W1975510659 @default.
• W3095865997 cites W1976166512 @default.
• W3095865997 cites W1991565131 @default.
• W3095865997 cites W2001003591 @default.
• W3095865997 cites W2004905652 @default.
• W3095865997 cites W2005385069 @default.
• W3095865997 cites W2007345646 @default.
• W3095865997 cites W2009740169 @default.
• W3095865997 cites W2012825205 @default.
• W3095865997 cites W2013666305 @default.
• W3095865997 cites W2014494588 @default.
• W3095865997 cites W2018021139 @default.
• W3095865997 cites W2029707852 @default.
• W3095865997 cites W2032229342 @default.
• W3095865997 cites W2041229701 @default.
• W3095865997 cites W2041557338 @default.
• W3095865997 cites W2043902057 @default.
• W3095865997 cites W2045267697 @default.
• W3095865997 cites W2052927837 @default.
• W3095865997 cites W2054388625 @default.
• W3095865997 cites W2057700073 @default.
• W3095865997 cites W2057899190 @default.
• W3095865997 cites W2060568634 @default.
• W3095865997 cites W2063848772 @default.
• W3095865997 cites W2064514960 @default.
• W3095865997 cites W2068879317 @default.
• W3095865997 cites W2069027839 @default.
• W3095865997 cites W2070782607 @default.
• W3095865997 cites W2071483359 @default.
• W3095865997 cites W2076759530 @default.
• W3095865997 cites W2079396470 @default.
• W3095865997 cites W2080713395 @default.
• W3095865997 cites W2081619699 @default.
• W3095865997 cites W2081706834 @default.
• W3095865997 cites W2084509977 @default.
• W3095865997 cites W2087362313 @default.
• W3095865997 cites W2090620788 @default.
• W3095865997 cites W2092791231 @default.
• W3095865997 cites W2093358915 @default.
• W3095865997 cites W2100784500 @default.
• W3095865997 cites W2101295479 @default.
• W3095865997 cites W2107522917 @default.
• W3095865997 cites W2114655589 @default.
• W3095865997 cites W2117336678 @default.
• W3095865997 cites W2137760199 @default.
• W3095865997 cites W2148957789 @default.
• W3095865997 cites W2154118705 @default.
• W3095865997 cites W2161771297 @default.
• W3095865997 cites W2169322502 @default.
• W3095865997 cites W2169324918 @default.
• W3095865997 cites W2170149943 @default.
• W3095865997 cites W2207047877 @default.
• W3095865997 cites W2401922463 @default.
• W3095865997 cites W2620344049 @default.
• W3095865997 cites W2622584689 @default.
• W3095865997 cites W2738378996 @default.
• W3095865997 cites W2785329869 @default.
• W3095865997 cites W2789355534 @default.
• W3095865997 cites W3037936818 @default.
• W3095865997 cites W4244267297 @default.
• W3095865997 cites W4296217171 @default.
• W3095865997 cites W44722726 @default.
• W3095865997 doi "https://doi.org/10.1016/j.brainresbull.2020.10.018" @default.
• W3095865997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33147520" @default.
• W3095865997 hasPublicationYear "2021" @default.
• W3095865997 type Work @default.
• W3095865997 sameAs 3095865997 @default.
• W3095865997 citedByCount "4" @default.
• W3095865997 countsByYear W30958659972021 @default.
• W3095865997 countsByYear W30958659972022 @default.
• W3095865997 countsByYear W30958659972023 @default.
• W3095865997 crossrefType "journal-article" @default.
• W3095865997 hasAuthorship W3095865997A5054504895 @default.
• W3095865997 hasAuthorship W3095865997A5088875879 @default.
• W3095865997 hasConcept C104317684 @default.
• W3095865997 hasConcept C126322002 @default.
• W3095865997 hasConcept C127716648 @default.
• W3095865997 hasConcept C15744967 @default.
• W3095865997 hasConcept C169760540 @default.
• W3095865997 hasConcept C2776525014 @default.
• W3095865997 hasConcept C2778261627 @default.
• W3095865997 hasConcept C2778559928 @default.
• W3095865997 hasConcept C2779134260 @default.
• W3095865997 hasConcept C2781313278 @default.
• W3095865997 hasConcept C54355233 @default.

• next