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• W3095872590 abstract "Mild ovarian stimulation has emerged as an alternative to conventional IVF with the advantages of being more patient-friendly and less expensive. Inadequate data on pregnancy outcomes and concerns about the cycle cancellation rate (CCR) have prevented mild, or low-dose, IVF from gaining wide acceptance.To evaluate parallel-group randomised controlled trials (RCTs) on IVF where comparisons were made between a mild (≤150 IU daily dose) and conventional stimulation in terms of clinical outcomes and cost-effectiveness in patients described as poor, normal and non-polycystic ovary syndrome (PCOS) hyper-responders to IVF.Searches with no language restrictions were performed using Medline, Embase, Cochrane central, Pre-Medicine from January 1990 until April 2020, using pre-specified search terms. References of included studies were hand-searched as well as advance access articles to key journals. Only parallel-group RCTs that used ≤150 IU daily dose of gonadotrophin as mild-dose IVF (MD-IVF) and compared with a higher conventional dose (CD-IVF) were included. Studies were grouped under poor, normal or hyper-responders as described by the authors in their inclusion criteria. Women with PCOS were excluded in the hyper-responder group. The risk of bias was assessed as per Cochrane Handbook for the included studies. The quality of evidence (QoE) was assessed according to the GRADE system. PRISMA guidance was followed for review methodology.A total of 31 RCTs were included in the analysis: 15 in the poor, 14 in the normal and 2 in the hyper-responder group. Live birth rates (LBRs) per randomisation were similar following use of MD-IVF in poor (relative risk (RR) 0.91 (CI 0.68, 1.22)), normal (RR 0.88 (CI 0.69, 1.12)) and hyper-responders (RR 0.98 (CI 0.79, 1.22)) when compared to CD-IVF. QoE was moderate. Cumulative LBRs (5 RCTs, n = 2037) also were similar in all three patient types (RR 0.96 (CI 0.86 1.07) (moderate QoE). Risk of ovarian hyperstimulation syndrome was significantly less with MD-IVF than CD-IVF in both normal (RR 0.22 (CI 0.10, 0.50)) and hyper-responders (RR 0.47 (CI 0.31, 0.72)), with moderate QoE. The CCRs were comparable in poor (RR 1.33 (CI 0.96, 1.85)) and hyper-responders (RR 1.31 (CI 0.98, 1.77)) but increased with MD-IVF among normal responders (RR 2.08 (CI 1.38, 3.14)); all low to very low QoE. Although fewer oocytes were retrieved and fewer embryos created with MD-IVF, the proportion of high-grade embryos was similar in all three population types (low QoE). Compared to CD-IVF, MD-IVF was associated with less gonadotrophin use and lower cost.This updated review provides reassurance on using MD-IVF not only for the LBR per cycle but also for the cumulative LBR, with moderate QoE. With risks identified with 'freeze-all' strategies, it may be time to recommend mild-dose ovarian stimulation for IVF for all categories of women i.e. hyper, poor and normal responders to IVF." @default.
• W3095872590 created "2020-11-09" @default.
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• W3095872590 date "2020-11-04" @default.
• W3095872590 modified "2023-10-18" @default.
• W3095872590 title "Mild versus conventional ovarian stimulation for IVF in poor, normal and hyper-responders: a systematic review and meta-analysis" @default.
• W3095872590 cites W1451500388 @default.
• W3095872590 cites W1570563601 @default.
• W3095872590 cites W1576440264 @default.
• W3095872590 cites W1578770865 @default.
• W3095872590 cites W1862886758 @default.
• W3095872590 cites W1902769688 @default.
• W3095872590 cites W1963860611 @default.
• W3095872590 cites W1967343247 @default.
• W3095872590 cites W1972595047 @default.
• W3095872590 cites W1976150823 @default.
• W3095872590 cites W1982329134 @default.
• W3095872590 cites W1984678017 @default.
• W3095872590 cites W1984769489 @default.
• W3095872590 cites W1996458430 @default.
• W3095872590 cites W1997957784 @default.
• W3095872590 cites W2021719086 @default.
• W3095872590 cites W2029377433 @default.
• W3095872590 cites W2042141246 @default.
• W3095872590 cites W2053667400 @default.
• W3095872590 cites W2066132912 @default.
• W3095872590 cites W2070943782 @default.
• W3095872590 cites W2071636746 @default.
• W3095872590 cites W2088720796 @default.
• W3095872590 cites W2091637930 @default.
• W3095872590 cites W2099586829 @default.
• W3095872590 cites W2105251513 @default.
• W3095872590 cites W2105886230 @default.
• W3095872590 cites W2105951314 @default.
• W3095872590 cites W2115798190 @default.
• W3095872590 cites W2117470501 @default.
• W3095872590 cites W2117938050 @default.
• W3095872590 cites W2120594341 @default.
• W3095872590 cites W2128878511 @default.
• W3095872590 cites W2140822141 @default.
• W3095872590 cites W214436918 @default.
• W3095872590 cites W2148041594 @default.
• W3095872590 cites W2154363581 @default.
• W3095872590 cites W2157530749 @default.
• W3095872590 cites W2166169434 @default.
• W3095872590 cites W2170141366 @default.
• W3095872590 cites W2188341944 @default.
• W3095872590 cites W2193787234 @default.
• W3095872590 cites W2309188263 @default.
• W3095872590 cites W2325295806 @default.
• W3095872590 cites W2403855607 @default.
• W3095872590 cites W2407213898 @default.
• W3095872590 cites W2409188184 @default.
• W3095872590 cites W2415261364 @default.
• W3095872590 cites W2419563280 @default.
• W3095872590 cites W2477323585 @default.
• W3095872590 cites W2489186165 @default.
• W3095872590 cites W2508722938 @default.
• W3095872590 cites W2534633281 @default.
• W3095872590 cites W2551121237 @default.
• W3095872590 cites W2557007075 @default.
• W3095872590 cites W2591499539 @default.
• W3095872590 cites W2602837790 @default.
• W3095872590 cites W2616387910 @default.
• W3095872590 cites W2759579850 @default.
• W3095872590 cites W2767174764 @default.
• W3095872590 cites W2773254239 @default.
• W3095872590 cites W2781893134 @default.
• W3095872590 cites W2790863352 @default.
• W3095872590 cites W2799333698 @default.
• W3095872590 cites W2903585683 @default.
• W3095872590 cites W2994855904 @default.
• W3095872590 cites W3011036956 @default.
• W3095872590 cites W3013669487 @default.
• W3095872590 cites W3027410100 @default.
• W3095872590 cites W4245333082 @default.
• W3095872590 cites W4252439673 @default.
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• W3095872590 doi "https://doi.org/10.1093/humupd/dmaa035" @default.
• W3095872590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7902993" @default.
• W3095872590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33146690" @default.
• W3095872590 hasPublicationYear "2020" @default.
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