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- W3095900009 abstract "Diazoxide is the first line treatment for patients with hyperinsulinaemic hypoglycaemia (HH). The vast majority of patients tolerate diazoxide well without any major complications. However, diazoxide is known to cause several side effects including hypertrichosis, neutropaenia, thrombocytopaenia, hyperuricaemia and fluid retention. Pulmonary hypertension (PH) is a rare side effect of diazoxide and has been documented in several previous studies in addition to this study. The US Food and Drug Administration (FDA) issued a safety alert in September 2015 cautioning that diazoxide could lead to PH, which is characterized by an elevation of the pulmonary arterial pressure that consequently increases right ventricular afterload and results in right heart failure. Interestingly there are genetic causes of primary pulmonary hypertension due to defects in one of the genes (ABCC8 ) which also leads to congenital hyperinsulinism (1). The underlying risk factors and mechanisms which trigger PH in patients who are treated with diazoxide are not known. Potential risk factors based on a previous study include being born premature, respiratory failure and congenital heart disease (2)." @default.
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- W3095900009 date "2020-10-23" @default.
- W3095900009 modified "2023-09-29" @default.
- W3095900009 title "Diazoxide-induced pulmonary hypertension in hyperinsulinaemic hypoglycaemia: Recommendations from a multi-centre study in the United Kingdom" @default.
- W3095900009 doi "https://doi.org/10.1530/ey.17.2.2" @default.
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