Matches in SemOpenAlex for { <https://semopenalex.org/work/W3095909084> ?p ?o ?g. }
- W3095909084 abstract "In living cells, liquid condensates form in the cytoplasm and nucleoplasm via phase separation and regulate physiological processes. They also regulate aberrant aggregation of amyloid fibrils, a process linked to Alzheimer’s and Parkinson’s diseases. In the absence of condensates it has been shown that amyloid aggregation can be inhibited by molecular chaperones and rationally designed drugs. However it remains unknown how this drug- or chaperone-mediated inhibition of amyloid fibril aggregation is affected by phase-separated condensates. Here we study the interplay between protein aggregation, its inhibition and liquid-liquid phase separation. Our key finding is that the potency of inhibitors of amyloid formation can be strongly enhanced. We show that the corresponding mechanism relies on the colocalization of inhibitors and aggregates inside the liquid condensate. We provide experimentally testable physicochemical conditions under which the increase of inhibitor potency is most pronounced. Our work highlights the role of spatio-temporal heterogeneity in curtailing aberrant protein aggregation and suggests design principles for amyloid inhibitors accounting for partitioning of drugs into liquid condensates." @default.
- W3095909084 created "2020-11-09" @default.
- W3095909084 creator A5006983623 @default.
- W3095909084 creator A5030113789 @default.
- W3095909084 creator A5063432831 @default.
- W3095909084 date "2020-10-29" @default.
- W3095909084 modified "2023-10-18" @default.
- W3095909084 title "Liquid condensates increase potency of amyloid fibril inhibitors" @default.
- W3095909084 cites W1587588813 @default.
- W3095909084 cites W1952608303 @default.
- W3095909084 cites W1966923623 @default.
- W3095909084 cites W1970577444 @default.
- W3095909084 cites W1972726656 @default.
- W3095909084 cites W1973897761 @default.
- W3095909084 cites W1983267406 @default.
- W3095909084 cites W2016983199 @default.
- W3095909084 cites W2030325989 @default.
- W3095909084 cites W2069350490 @default.
- W3095909084 cites W2073687064 @default.
- W3095909084 cites W2076159058 @default.
- W3095909084 cites W2076250336 @default.
- W3095909084 cites W2094881767 @default.
- W3095909084 cites W2095441938 @default.
- W3095909084 cites W2114636181 @default.
- W3095909084 cites W2118878821 @default.
- W3095909084 cites W2139066576 @default.
- W3095909084 cites W2141852179 @default.
- W3095909084 cites W2148505202 @default.
- W3095909084 cites W2150860983 @default.
- W3095909084 cites W2152696868 @default.
- W3095909084 cites W2163687938 @default.
- W3095909084 cites W2165186407 @default.
- W3095909084 cites W2166056987 @default.
- W3095909084 cites W2300111670 @default.
- W3095909084 cites W2309071467 @default.
- W3095909084 cites W2482248702 @default.
- W3095909084 cites W2513709734 @default.
- W3095909084 cites W2517203221 @default.
- W3095909084 cites W2569905855 @default.
- W3095909084 cites W2590568317 @default.
- W3095909084 cites W2590982773 @default.
- W3095909084 cites W2665805494 @default.
- W3095909084 cites W2756821926 @default.
- W3095909084 cites W2791443716 @default.
- W3095909084 cites W2792531202 @default.
- W3095909084 cites W2817784260 @default.
- W3095909084 cites W2889732702 @default.
- W3095909084 cites W2913277250 @default.
- W3095909084 cites W2913940235 @default.
- W3095909084 cites W2914907359 @default.
- W3095909084 cites W2947366776 @default.
- W3095909084 cites W2953564001 @default.
- W3095909084 cites W2969298382 @default.
- W3095909084 cites W350959020 @default.
- W3095909084 doi "https://doi.org/10.1101/2020.10.29.360206" @default.
- W3095909084 hasPublicationYear "2020" @default.
- W3095909084 type Work @default.
- W3095909084 sameAs 3095909084 @default.
- W3095909084 citedByCount "0" @default.
- W3095909084 crossrefType "posted-content" @default.
- W3095909084 hasAuthorship W3095909084A5006983623 @default.
- W3095909084 hasAuthorship W3095909084A5030113789 @default.
- W3095909084 hasAuthorship W3095909084A5063432831 @default.
- W3095909084 hasBestOaLocation W30959090841 @default.
- W3095909084 hasConcept C12554922 @default.
- W3095909084 hasConcept C136238340 @default.
- W3095909084 hasConcept C142724271 @default.
- W3095909084 hasConcept C179104552 @default.
- W3095909084 hasConcept C185592680 @default.
- W3095909084 hasConcept C190062978 @default.
- W3095909084 hasConcept C202751555 @default.
- W3095909084 hasConcept C27523624 @default.
- W3095909084 hasConcept C2777633098 @default.
- W3095909084 hasConcept C2779134260 @default.
- W3095909084 hasConcept C2994168385 @default.
- W3095909084 hasConcept C3019447875 @default.
- W3095909084 hasConcept C40209533 @default.
- W3095909084 hasConcept C55493867 @default.
- W3095909084 hasConcept C57992300 @default.
- W3095909084 hasConcept C71924100 @default.
- W3095909084 hasConcept C86803240 @default.
- W3095909084 hasConcept C95444343 @default.
- W3095909084 hasConceptScore W3095909084C12554922 @default.
- W3095909084 hasConceptScore W3095909084C136238340 @default.
- W3095909084 hasConceptScore W3095909084C142724271 @default.
- W3095909084 hasConceptScore W3095909084C179104552 @default.
- W3095909084 hasConceptScore W3095909084C185592680 @default.
- W3095909084 hasConceptScore W3095909084C190062978 @default.
- W3095909084 hasConceptScore W3095909084C202751555 @default.
- W3095909084 hasConceptScore W3095909084C27523624 @default.
- W3095909084 hasConceptScore W3095909084C2777633098 @default.
- W3095909084 hasConceptScore W3095909084C2779134260 @default.
- W3095909084 hasConceptScore W3095909084C2994168385 @default.
- W3095909084 hasConceptScore W3095909084C3019447875 @default.
- W3095909084 hasConceptScore W3095909084C40209533 @default.
- W3095909084 hasConceptScore W3095909084C55493867 @default.
- W3095909084 hasConceptScore W3095909084C57992300 @default.
- W3095909084 hasConceptScore W3095909084C71924100 @default.
- W3095909084 hasConceptScore W3095909084C86803240 @default.
- W3095909084 hasConceptScore W3095909084C95444343 @default.