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• W3095964518 endingPage "111437" @default.
• W3095964518 startingPage "111437" @default.
• W3095964518 abstract "Chemodynamic therapy (CDT), inducing tumor cell apoptosis through Fenton reaction to produce hydroxyl radical (·OH), is an emerging cancer treatment technology. Highly efficient Fenton catalytic reactions usually take place at a low pH environment. Utilizing graphitic carbon nitride supported hemin and Au nanoparticles (g-C3N4/hemin/Au) as a novel biomimetic nanocatalyst, we achieve an enhanced CDT for inducing tumor cell apoptosis in the presence of excess H2O2, and reveal the molecular events during the CDT-induced apoptosis. The prepared g-C3N4/hemin/Au nanohybrids exhibit excellent Fenton catalytic activity for the generation of highly toxic ·OH at weak acidic and neutral condition, which breaks through the limitation of traditional acidity-dependent response. The Fenton catalytic mechanism was also studied. The Fenton efficiency is primarily enhanced by the high affinity between nanohybrids and H2O2, and the transformation of Fe(III) to Fe(IV)=O without the formation of iron hydrate precipitation. Moreover, the intracellular molecular events during the CDT process were monitored. Phenylalanine metabolism was perturbed with protein degradation and DNA structures were damaged, which eventually lead to cell apoptosis. This study provides a significant guidance for the further development of more effective CDT platforms." @default.
• W3095964518 created "2020-11-09" @default.
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• W3095964518 date "2021-01-01" @default.
• W3095964518 modified "2023-10-18" @default.
• W3095964518 title "Enhanced chemodynamic therapy at weak acidic pH based on g-C3N4-supported hemin/Au nanoplatform and cell apoptosis monitoring during treatment" @default.
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• W3095964518 doi "https://doi.org/10.1016/j.colsurfb.2020.111437" @default.
• W3095964518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33166930" @default.
• W3095964518 hasPublicationYear "2021" @default.
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