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- W3095965908 abstract "Zeolite Y-gelatin composite was used as a drug carrier/matrix for oral drug delivery system. Zerumbone as a model drug isolated from Zingiber Zerumbet (L) Smith rhizomes was loaded first into zeolite Y before homogenously blending with gelatin solution. The cross-linking of final composite was achieved via cross-linking with glutaraldehyde for 24 hours. Brunauer-Emmet-Teller method (BET) of pore analysis was done in order to determine zerumbone loading into zeolite Y. The effects of cross-linking were investigated using swelling test, x-ray diffraction (XRD) and thermal gravimetric analyser (TGA) analysis. BET pore analysis confirms successful zerumbone loading into zeolite Y. Swelling analyses suggested that concentration of glutaraldehyde at 0.2 v/v% is sufficient to cross-link the composite in order to withstand pH variations in human gastrointestinal tract for 24 hours. XRD analysis expressing the stabilizing effect of zeolite Y on drug as it maintains its structure even after drug loading and cross-linking does not alter the final structure of composite. However, TGA analysis verified that cross-linking improved thermal stability of the gelatin composites, therefore making it possible for oral controlled release application." @default.
- W3095965908 created "2020-11-09" @default.
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- W3095965908 date "2020-01-01" @default.
- W3095965908 modified "2023-10-17" @default.
- W3095965908 title "Synthesis and characterization of cross-linked zerumbone loaded zeolite Y-gelatin for oral controlled release" @default.
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- W3095965908 doi "https://doi.org/10.1063/5.0023157" @default.
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