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- W3096001549 endingPage "925" @default.
- W3096001549 startingPage "925" @default.
- W3096001549 abstract "Influenza is an important research subject around the world because of its threat to humanity. Influenza A virus (IAV) causes seasonal epidemics and sporadic, but dangerous pandemics. A rapid antigen changes and recombination of the viral RNA genome contribute to the reduced effectiveness of vaccination and anti-influenza drugs. Hence, there is a necessity to develop new antiviral drugs and strategies to limit the influenza spread. IAV is a single-stranded negative sense RNA virus with a genome (viral RNA—vRNA) consisting of eight segments. Segments within influenza virion are assembled into viral ribonucleoprotein (vRNP) complexes that are independent transcription-replication units. Each step in the influenza life cycle is regulated by the RNA and is dependent on its interplay and dynamics. Therefore, viral RNA can be a proper target to design novel therapeutics. Here, we briefly described examples of anti-influenza strategies based on the antisense oligonucleotide (ASO), small interfering RNA (siRNA), microRNA (miRNA) and catalytic nucleic acids. In particular we focused on the vRNA structure-function relationship as well as presented the advantages of using secondary structure information in predicting therapeutic targets and the potential future of this field." @default.
- W3096001549 created "2020-11-09" @default.
- W3096001549 creator A5010668582 @default.
- W3096001549 creator A5043782644 @default.
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- W3096001549 creator A5066085553 @default.
- W3096001549 creator A5068516950 @default.
- W3096001549 creator A5078966154 @default.
- W3096001549 date "2020-11-07" @default.
- W3096001549 modified "2023-10-06" @default.
- W3096001549 title "RNA Secondary Structure as a First Step for Rational Design of the Oligonucleotides towards Inhibition of Influenza A Virus Replication" @default.
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