FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096006712> ?p ?o ?g. }

• W3096006712 endingPage "7992" @default.
• W3096006712 startingPage "7992" @default.
• W3096006712 abstract "Stimulus-dependent elevation of intracellular Ca2+ affects gene expression via well-documented calmodulin-mediated signaling pathways. Recently, we found that the addition of extra- and intracellular Ca2+ chelators increased, rather than decreased, the number of genes expressed, and that this is affected by the elevation of [Na+]i/[K+]i-ratio. This assumes the existence of a novel Na+i/K+i-mediated Ca2+i-independent mechanism of excitation-transcription coupling. To identify upstream Na+i/K+i-sensitive genes, we examined the kinetics of transcriptomic changes in human umbilical vein endothelial cells (HUVEC) subjected to Na,K-ATPase inhibition by ouabain or K+-free medium. According to our data, microRNAs, transcription factors, and proteins involved in immune response and inflammation might be considered as key components of Na+i/K+i-mediated excitation-transcription coupling. Special attention was focused on the FOS gene and the possible mechanism of transcription regulation via G-quadruplexes, non-canonical secondary structures of nucleic acids, whose stability depends on [Na+]i/[K+]i-ratio. Verification of the [Na+]i/[K+]i-sensitive transcription regulation mechanism should be continued in forthcoming studies." @default.
• W3096006712 created "2020-11-09" @default.
• W3096006712 creator A5008174160 @default.
• W3096006712 creator A5031351161 @default.
• W3096006712 creator A5053115271 @default.
• W3096006712 creator A5068046329 @default.
• W3096006712 creator A5077948097 @default.
• W3096006712 creator A5079920784 @default.
• W3096006712 date "2020-10-27" @default.
• W3096006712 modified "2023-09-27" @default.
• W3096006712 title "Transcriptomic Changes in Endothelial Cells Triggered by Na,K-ATPase Inhibition: A Search for Upstream Na+i/K+i Sensitive Genes" @default.
• W3096006712 cites W1522137781 @default.
• W3096006712 cites W1606272701 @default.
• W3096006712 cites W1684778245 @default.
• W3096006712 cites W1899877571 @default.
• W3096006712 cites W1966422568 @default.
• W3096006712 cites W1968436532 @default.
• W3096006712 cites W1979701388 @default.
• W3096006712 cites W1985356991 @default.
• W3096006712 cites W1987401644 @default.
• W3096006712 cites W2003820886 @default.
• W3096006712 cites W2004631970 @default.
• W3096006712 cites W2007128749 @default.
• W3096006712 cites W2020949285 @default.
• W3096006712 cites W2031272027 @default.
• W3096006712 cites W2035768382 @default.
• W3096006712 cites W2038068698 @default.
• W3096006712 cites W2042293318 @default.
• W3096006712 cites W2043841998 @default.
• W3096006712 cites W2045284889 @default.
• W3096006712 cites W2045815424 @default.
• W3096006712 cites W2049285731 @default.
• W3096006712 cites W2049414505 @default.
• W3096006712 cites W2050902176 @default.
• W3096006712 cites W2052977964 @default.
• W3096006712 cites W2053084152 @default.
• W3096006712 cites W2056025181 @default.
• W3096006712 cites W2066461638 @default.
• W3096006712 cites W2069151092 @default.
• W3096006712 cites W2076335297 @default.
• W3096006712 cites W2086233060 @default.
• W3096006712 cites W2100837269 @default.
• W3096006712 cites W2110225954 @default.
• W3096006712 cites W2143617499 @default.
• W3096006712 cites W2144470409 @default.
• W3096006712 cites W2159675211 @default.
• W3096006712 cites W2186127765 @default.
• W3096006712 cites W2294798173 @default.
• W3096006712 cites W2321965258 @default.
• W3096006712 cites W2335815721 @default.
• W3096006712 cites W2463175763 @default.
• W3096006712 cites W2552740654 @default.
• W3096006712 cites W2597879187 @default.
• W3096006712 cites W2599601965 @default.
• W3096006712 cites W2734351602 @default.
• W3096006712 cites W2783354632 @default.
• W3096006712 cites W2792386469 @default.
• W3096006712 cites W2885527150 @default.
• W3096006712 cites W2893800126 @default.
• W3096006712 cites W2902532424 @default.
• W3096006712 cites W2905299773 @default.
• W3096006712 cites W2917853350 @default.
• W3096006712 cites W2923622847 @default.
• W3096006712 cites W2966334511 @default.
• W3096006712 cites W2967789343 @default.
• W3096006712 cites W2968022676 @default.
• W3096006712 cites W2972734466 @default.
• W3096006712 cites W2977371516 @default.
• W3096006712 cites W2981220896 @default.
• W3096006712 cites W2986184282 @default.
• W3096006712 cites W2986844469 @default.
• W3096006712 cites W2996638575 @default.
• W3096006712 cites W3003953372 @default.
• W3096006712 cites W3083696578 @default.
• W3096006712 doi "https://doi.org/10.3390/ijms21217992" @default.
• W3096006712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7662270" @default.
• W3096006712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33121152" @default.
• W3096006712 hasPublicationYear "2020" @default.
• W3096006712 type Work @default.
• W3096006712 sameAs 3096006712 @default.
• W3096006712 citedByCount "2" @default.
• W3096006712 countsByYear W30960067122021 @default.
• W3096006712 countsByYear W30960067122023 @default.
• W3096006712 crossrefType "journal-article" @default.
• W3096006712 hasAuthorship W3096006712A5008174160 @default.
• W3096006712 hasAuthorship W3096006712A5031351161 @default.
• W3096006712 hasAuthorship W3096006712A5053115271 @default.
• W3096006712 hasAuthorship W3096006712A5068046329 @default.
• W3096006712 hasAuthorship W3096006712A5077948097 @default.
• W3096006712 hasAuthorship W3096006712A5079920784 @default.
• W3096006712 hasBestOaLocation W30960067121 @default.
• W3096006712 hasConcept C104317684 @default.
• W3096006712 hasConcept C138885662 @default.
• W3096006712 hasConcept C150194340 @default.
• W3096006712 hasConcept C153911025 @default.
• W3096006712 hasConcept C162317418 @default.
• W3096006712 hasConcept C178790620 @default.
• W3096006712 hasConcept C179926584 @default.

• next