FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096006904> ?p ?o ?g. }

• W3096006904 endingPage "1969" @default.
• W3096006904 startingPage "1963" @default.
• W3096006904 abstract "Aims Recently a limited sampling strategy (LSS) for determination of metformin' pharmacokinetics was developed. The LSS utilizes the plasma concentration of metformin 3 and 10 hours after oral intake of a single dose to estimate the area under the concentration–time curve up to 24 hours (AUC 0–24h ). The main purpose of this study was to support the feasibility of this strategy in a large prospective trial. Methods Volunteers orally ingested two 500‐mg tablets of metformin hydrochloride. A blood sample was drawn three and ten hours after the ingestion. Urine was collected for 0–10 and 10–24 hours and urine volumes recorded. The AUC 0–24h was calculated using the equation AUC 0–24h = 4.779 * C 3 + 13.174 * C 10 . Additionally, all participants were genotyped for the single‐nucleotide polymorphism A270S in OCT2 , g.‐66 T > C in MATE1 , R61C, G465R, G401S and the deletion M420del in OCT1 . Results In total, 212 healthy volunteers participated. The median (25th ‐ 75th interquartile range) AUC 0 − 24h , CL renal , C 3 and C 10 , were 10 600 (8470–12 500) ng* hr* mL −1 , 29 (24–34) L* hour −1 , 1460 (1180–1770) and 260 (200–330) ng* mL −1 , respectively, which is in agreement with our previous results. GFR i was correlated with metformin AUC and CL renal ( P < .001). As expected, we found a great pharmacokinetic interindividual variability among the volunteers and no effect of the OCT1 genotype on the AUC 0 − 24h . We were unable to reproduce our previous finding of a gene–gene interaction ( OCT2 and MATE1 ) effect on CL renal in this cohort. Conclusion This study further supports the use of the 2‐point LSS algorithm in large pharmacokinetic trials." @default.
• W3096006904 created "2020-11-09" @default.
• W3096006904 creator A5004435306 @default.
• W3096006904 creator A5005287400 @default.
• W3096006904 creator A5020963806 @default.
• W3096006904 creator A5035596840 @default.
• W3096006904 creator A5059718242 @default.
• W3096006904 creator A5082284156 @default.
• W3096006904 date "2020-11-13" @default.
• W3096006904 modified "2023-09-25" @default.
• W3096006904 title "Using a limited sampling strategy to investigate the interindividual pharmacokinetic variability in metformin: A large prospective trial" @default.
• W3096006904 cites W1984565251 @default.
• W3096006904 cites W1996510156 @default.
• W3096006904 cites W2020705541 @default.
• W3096006904 cites W2023434765 @default.
• W3096006904 cites W2028615902 @default.
• W3096006904 cites W2039905469 @default.
• W3096006904 cites W2044276788 @default.
• W3096006904 cites W2064278757 @default.
• W3096006904 cites W2086818413 @default.
• W3096006904 cites W2110755408 @default.
• W3096006904 cites W2158119880 @default.
• W3096006904 cites W2161910253 @default.
• W3096006904 cites W2168993879 @default.
• W3096006904 cites W2170852135 @default.
• W3096006904 cites W2255443535 @default.
• W3096006904 cites W2467763344 @default.
• W3096006904 cites W2613761246 @default.
• W3096006904 cites W2740176924 @default.
• W3096006904 cites W2743010525 @default.
• W3096006904 cites W2788374915 @default.
• W3096006904 cites W2791844482 @default.
• W3096006904 cites W2793906897 @default.
• W3096006904 cites W2809455517 @default.
• W3096006904 cites W2894301746 @default.
• W3096006904 cites W2969928163 @default.
• W3096006904 cites W2972869264 @default.
• W3096006904 cites W2988660670 @default.
• W3096006904 doi "https://doi.org/10.1111/bcp.14591" @default.
• W3096006904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33118168" @default.
• W3096006904 hasPublicationYear "2020" @default.
• W3096006904 type Work @default.
• W3096006904 sameAs 3096006904 @default.
• W3096006904 citedByCount "8" @default.
• W3096006904 countsByYear W30960069042021 @default.
• W3096006904 countsByYear W30960069042022 @default.
• W3096006904 countsByYear W30960069042023 @default.
• W3096006904 crossrefType "journal-article" @default.
• W3096006904 hasAuthorship W3096006904A5004435306 @default.
• W3096006904 hasAuthorship W3096006904A5005287400 @default.
• W3096006904 hasAuthorship W3096006904A5020963806 @default.
• W3096006904 hasAuthorship W3096006904A5035596840 @default.
• W3096006904 hasAuthorship W3096006904A5059718242 @default.
• W3096006904 hasAuthorship W3096006904A5082284156 @default.
• W3096006904 hasBestOaLocation W30960069041 @default.
• W3096006904 hasConcept C112705442 @default.
• W3096006904 hasConcept C119060515 @default.
• W3096006904 hasConcept C126322002 @default.
• W3096006904 hasConcept C126894567 @default.
• W3096006904 hasConcept C188816634 @default.
• W3096006904 hasConcept C2779306644 @default.
• W3096006904 hasConcept C2780026642 @default.
• W3096006904 hasConcept C2780323712 @default.
• W3096006904 hasConcept C2988731192 @default.
• W3096006904 hasConcept C71924100 @default.
• W3096006904 hasConcept C76318530 @default.
• W3096006904 hasConcept C98274493 @default.
• W3096006904 hasConceptScore W3096006904C112705442 @default.
• W3096006904 hasConceptScore W3096006904C119060515 @default.
• W3096006904 hasConceptScore W3096006904C126322002 @default.
• W3096006904 hasConceptScore W3096006904C126894567 @default.
• W3096006904 hasConceptScore W3096006904C188816634 @default.
• W3096006904 hasConceptScore W3096006904C2779306644 @default.
• W3096006904 hasConceptScore W3096006904C2780026642 @default.
• W3096006904 hasConceptScore W3096006904C2780323712 @default.
• W3096006904 hasConceptScore W3096006904C2988731192 @default.
• W3096006904 hasConceptScore W3096006904C71924100 @default.
• W3096006904 hasConceptScore W3096006904C76318530 @default.
• W3096006904 hasConceptScore W3096006904C98274493 @default.
• W3096006904 hasFunder F4320322928 @default.
• W3096006904 hasFunder F4320323799 @default.
• W3096006904 hasIssue "4" @default.
• W3096006904 hasLocation W30960069041 @default.
• W3096006904 hasLocation W30960069042 @default.
• W3096006904 hasOpenAccess W3096006904 @default.
• W3096006904 hasPrimaryLocation W30960069041 @default.
• W3096006904 hasRelatedWork W1965073591 @default.
• W3096006904 hasRelatedWork W2004124514 @default.
• W3096006904 hasRelatedWork W2019391076 @default.
• W3096006904 hasRelatedWork W2047409028 @default.
• W3096006904 hasRelatedWork W2066320494 @default.
• W3096006904 hasRelatedWork W2142080078 @default.
• W3096006904 hasRelatedWork W3092052599 @default.
• W3096006904 hasRelatedWork W3133097852 @default.
• W3096006904 hasRelatedWork W4285393230 @default.
• W3096006904 hasRelatedWork W4311933079 @default.
• W3096006904 hasVolume "87" @default.
• W3096006904 isParatext "false" @default.

• next