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- W3096026539 endingPage "994" @default.
- W3096026539 startingPage "967" @default.
- W3096026539 abstract "Mitochondrial disorders manifest enormous genetic and clinical heterogeneity - they can appear at any age, present with various phenotypes affecting any organ, and display any mode of inheritance. What mitochondrial diseases do have in common, is impairment of respiratory chain activity, which is responsible for more than 90% of energy production within cells. While diagnostics of mitochondrial disorders has been accelerated by introducing Next-Generation Sequencing techniques in recent years, the treatment options are still very limited. For many patients only a supportive or symptomatic therapy is available at the moment. However, decades of basic and preclinical research have uncovered potential target points and numerous compounds or interventions are now subjects of clinical trials. In this review, we focus on current and emerging therapeutic approaches towards the treatment of mitochondrial disorders. We focus on small compounds, metabolic interference, such as endurance training or ketogenic diet and also on genomic approaches." @default.
- W3096026539 created "2020-11-09" @default.
- W3096026539 creator A5062456767 @default.
- W3096026539 creator A5082164776 @default.
- W3096026539 creator A5084061838 @default.
- W3096026539 creator A5085635070 @default.
- W3096026539 creator A5086545845 @default.
- W3096026539 date "2020-12-22" @default.
- W3096026539 modified "2023-10-18" @default.
- W3096026539 title "Current progress in the therapeutic options for mitochondrial disorders." @default.
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