FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096032131> ?p ?o ?g. }

• W3096032131 endingPage "6360" @default.
• W3096032131 startingPage "6346" @default.
• W3096032131 abstract "Background Chronic liver injury (CLI) is now a worldwide disease. However, there is no effective treatment. Pyroptosis plays an essential role in CLI. Dihydromyricetin (DHM) resists oxidation and protects the liver. We hypothesize that the beneficial effect of DHM on CLI is related to its effect on the expression of pyroptosis-related molecules. Therefore, we studied the influence of DHM on CLI and pyroptosis. Aim To study the role of pyroptosis in the pathogenesis of CLI and the therapeutic mechanism of DHM. Methods Thirty-two mice were randomly divided into four groups: The control group was injected with olive oil, the carbon tetrachloride (CCl4) group was injected with CCl4, the vehicle group was injected with hydroxypropyl-β-cyclodextrin while injecting CCl4 and the DHM group was injected with DHM while injecting CCl4. After four weeks of treatment, liver tissues from the mice were stained with hematoxylin and eosin, and oil red O. Blood was collected from the angular vein for serological analysis. The severity of CLI was estimated. Some liver tissue was sampled for immunohistochemistry, Western blotting and quantitative reverse transcription PCR to observe the changes in pyroptosis-related molecules. Results Serum total cholesterol, low density lipoprotein, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the CCl4 group were higher than those in the control group, and serum total cholesterol, low density lipoprotein, AST and ALT in the DHM group were lower than those in the vehicle group. Hematoxylin and eosin and oil red O staining showed that there were more lipid droplets in the CCl4 group than in the control group, and there were fewer lipid droplets in the DHM group than in the vehicle group. Western blotting showed that the expression of the pyroptosis-related molecules caspase-1, NOD-, LRR- and pyrin domain-containing 3 (NLRP3) and gasdermin D (GSDMD)-N in the CCl4 group was higher than that in the control group, while expression of these proteins in the DHM group was lower than that in the vehicle group. Quantitative reverse transcription PCR results showed that the expression of the pyroptosis-related genes caspase-1, NLRP3, GSDMD and interleukin-1β (IL-1β) in the CCl4 group was higher than that in the control group, while there was no significant change in NLRP3 and caspase-1 expression in the DHM group compared with that in the vehicle group, and the expression of GSDMD and IL-1β was decreased. Conclusion DHM improves CCl4-induced CLI and regulates the pyroptosis pathway in hepatocytes. DHM may be a potential therapeutic agent for CLI." @default.
• W3096032131 created "2020-11-09" @default.
• W3096032131 creator A5007603233 @default.
• W3096032131 creator A5016738980 @default.
• W3096032131 creator A5033098099 @default.
• W3096032131 creator A5036387670 @default.
• W3096032131 creator A5043381179 @default.
• W3096032131 creator A5050054072 @default.
• W3096032131 creator A5059267167 @default.
• W3096032131 creator A5066332067 @default.
• W3096032131 creator A5085672523 @default.
• W3096032131 date "2020-11-07" @default.
• W3096032131 modified "2023-10-16" @default.
• W3096032131 title "Dihydromyricetin ameliorates chronic liver injury by reducing pyroptosis" @default.
• W3096032131 cites W1567905846 @default.
• W3096032131 cites W1791551778 @default.
• W3096032131 cites W1864325817 @default.
• W3096032131 cites W1891826181 @default.
• W3096032131 cites W1965588383 @default.
• W3096032131 cites W1979327008 @default.
• W3096032131 cites W1987186266 @default.
• W3096032131 cites W2011295880 @default.
• W3096032131 cites W2011934032 @default.
• W3096032131 cites W2041657200 @default.
• W3096032131 cites W2116342732 @default.
• W3096032131 cites W2117497424 @default.
• W3096032131 cites W2123754370 @default.
• W3096032131 cites W2144467901 @default.
• W3096032131 cites W2411482377 @default.
• W3096032131 cites W2431987552 @default.
• W3096032131 cites W2517997111 @default.
• W3096032131 cites W2536337124 @default.
• W3096032131 cites W2565671276 @default.
• W3096032131 cites W2607373498 @default.
• W3096032131 cites W2747363599 @default.
• W3096032131 cites W2776342909 @default.
• W3096032131 cites W2784015011 @default.
• W3096032131 cites W2790198401 @default.
• W3096032131 cites W2794352179 @default.
• W3096032131 cites W2800636005 @default.
• W3096032131 cites W2804281681 @default.
• W3096032131 cites W2818139375 @default.
• W3096032131 cites W2892849077 @default.
• W3096032131 cites W2897382070 @default.
• W3096032131 cites W2898097157 @default.
• W3096032131 cites W2919608987 @default.
• W3096032131 cites W2921353174 @default.
• W3096032131 cites W2936758967 @default.
• W3096032131 cites W2948767830 @default.
• W3096032131 cites W2948845640 @default.
• W3096032131 cites W2976536712 @default.
• W3096032131 cites W3014436063 @default.
• W3096032131 doi "https://doi.org/10.3748/wjg.v26.i41.6346" @default.
• W3096032131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7656208" @default.
• W3096032131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33244197" @default.
• W3096032131 hasPublicationYear "2020" @default.
• W3096032131 type Work @default.
• W3096032131 sameAs 3096032131 @default.
• W3096032131 citedByCount "16" @default.
• W3096032131 countsByYear W30960321312021 @default.
• W3096032131 countsByYear W30960321312022 @default.
• W3096032131 countsByYear W30960321312023 @default.
• W3096032131 crossrefType "journal-article" @default.
• W3096032131 hasAuthorship W3096032131A5007603233 @default.
• W3096032131 hasAuthorship W3096032131A5016738980 @default.
• W3096032131 hasAuthorship W3096032131A5033098099 @default.
• W3096032131 hasAuthorship W3096032131A5036387670 @default.
• W3096032131 hasAuthorship W3096032131A5043381179 @default.
• W3096032131 hasAuthorship W3096032131A5050054072 @default.
• W3096032131 hasAuthorship W3096032131A5059267167 @default.
• W3096032131 hasAuthorship W3096032131A5066332067 @default.
• W3096032131 hasAuthorship W3096032131A5085672523 @default.
• W3096032131 hasBestOaLocation W30960321311 @default.
• W3096032131 hasConcept C126322002 @default.
• W3096032131 hasConcept C17172800 @default.
• W3096032131 hasConcept C2776637226 @default.
• W3096032131 hasConcept C2776914184 @default.
• W3096032131 hasConcept C2777209026 @default.
• W3096032131 hasConcept C71924100 @default.
• W3096032131 hasConcept C90924648 @default.
• W3096032131 hasConcept C98274493 @default.
• W3096032131 hasConceptScore W3096032131C126322002 @default.
• W3096032131 hasConceptScore W3096032131C17172800 @default.
• W3096032131 hasConceptScore W3096032131C2776637226 @default.
• W3096032131 hasConceptScore W3096032131C2776914184 @default.
• W3096032131 hasConceptScore W3096032131C2777209026 @default.
• W3096032131 hasConceptScore W3096032131C71924100 @default.
• W3096032131 hasConceptScore W3096032131C90924648 @default.
• W3096032131 hasConceptScore W3096032131C98274493 @default.
• W3096032131 hasIssue "41" @default.
• W3096032131 hasLocation W30960321311 @default.
• W3096032131 hasLocation W30960321312 @default.
• W3096032131 hasOpenAccess W3096032131 @default.
• W3096032131 hasPrimaryLocation W30960321311 @default.
• W3096032131 hasRelatedWork W2015682186 @default.
• W3096032131 hasRelatedWork W2354901326 @default.
• W3096032131 hasRelatedWork W2913483701 @default.
• W3096032131 hasRelatedWork W3046867298 @default.

• next