Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096064145> ?p ?o ?g. }
- W3096064145 abstract "Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against SARS-CoV-2. Moreover, passively administered antibodies are among the most promising therapeutic and prophylactic anti-SARS-CoV-2 agents. However, the degree to which SARS-CoV-2 will adapt to evade neutralizing antibodies is unclear. Using a recombinant chimeric VSV/SARS-CoV-2 reporter virus, we show that functional SARS-CoV-2 S protein variants with mutations in the receptor-binding domain (RBD) and N-terminal domain that confer resistance to monoclonal antibodies or convalescent plasma can be readily selected. Notably, SARS-CoV-2 S variants that resist commonly elicited neutralizing antibodies are now present at low frequencies in circulating SARS-CoV-2 populations. Finally, the emergence of antibody-resistant SARS-CoV-2 variants that might limit the therapeutic usefulness of monoclonal antibodies can be mitigated by the use of antibody combinations that target distinct neutralizing epitopes." @default.
- W3096064145 created "2020-11-09" @default.
- W3096064145 creator A5001960560 @default.
- W3096064145 creator A5003699560 @default.
- W3096064145 creator A5015157595 @default.
- W3096064145 creator A5017806204 @default.
- W3096064145 creator A5019683467 @default.
- W3096064145 creator A5025789964 @default.
- W3096064145 creator A5026966580 @default.
- W3096064145 creator A5027633474 @default.
- W3096064145 creator A5036306540 @default.
- W3096064145 creator A5036442748 @default.
- W3096064145 creator A5043464539 @default.
- W3096064145 creator A5053636210 @default.
- W3096064145 creator A5054688016 @default.
- W3096064145 creator A5055393258 @default.
- W3096064145 creator A5063741386 @default.
- W3096064145 creator A5064231841 @default.
- W3096064145 creator A5066892149 @default.
- W3096064145 creator A5070384842 @default.
- W3096064145 creator A5070436278 @default.
- W3096064145 creator A5072949815 @default.
- W3096064145 creator A5080917884 @default.
- W3096064145 creator A5080976451 @default.
- W3096064145 creator A5085094175 @default.
- W3096064145 creator A5086285636 @default.
- W3096064145 date "2020-10-28" @default.
- W3096064145 modified "2023-10-04" @default.
- W3096064145 title "Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants" @default.
- W3096064145 cites W1563437181 @default.
- W3096064145 cites W1877486762 @default.
- W3096064145 cites W1965669216 @default.
- W3096064145 cites W2020939898 @default.
- W3096064145 cites W2047024427 @default.
- W3096064145 cites W2093019529 @default.
- W3096064145 cites W2152287937 @default.
- W3096064145 cites W2160358721 @default.
- W3096064145 cites W2587970647 @default.
- W3096064145 cites W2797973264 @default.
- W3096064145 cites W2964709937 @default.
- W3096064145 cites W3010441732 @default.
- W3096064145 cites W3013893137 @default.
- W3096064145 cites W3014853902 @default.
- W3096064145 cites W3017017672 @default.
- W3096064145 cites W3017300461 @default.
- W3096064145 cites W3021283406 @default.
- W3096064145 cites W3023013969 @default.
- W3096064145 cites W3024602798 @default.
- W3096064145 cites W3029682964 @default.
- W3096064145 cites W3032255042 @default.
- W3096064145 cites W3033450058 @default.
- W3096064145 cites W3034202401 @default.
- W3096064145 cites W3034425032 @default.
- W3096064145 cites W3034548712 @default.
- W3096064145 cites W3034816694 @default.
- W3096064145 cites W3035440057 @default.
- W3096064145 cites W3035459690 @default.
- W3096064145 cites W3035920796 @default.
- W3096064145 cites W3036386821 @default.
- W3096064145 cites W3036607916 @default.
- W3096064145 cites W3039901154 @default.
- W3096064145 cites W3041564586 @default.
- W3096064145 cites W3042323010 @default.
- W3096064145 cites W3043124965 @default.
- W3096064145 cites W3044660350 @default.
- W3096064145 cites W3044702419 @default.
- W3096064145 cites W3044914269 @default.
- W3096064145 cites W3080458234 @default.
- W3096064145 cites W3082387069 @default.
- W3096064145 cites W3082497697 @default.
- W3096064145 cites W3083812755 @default.
- W3096064145 cites W3083815322 @default.
- W3096064145 cites W3085504216 @default.
- W3096064145 cites W3087137753 @default.
- W3096064145 cites W3087521091 @default.
- W3096064145 cites W3087581820 @default.
- W3096064145 cites W3092610091 @default.
- W3096064145 cites W4206712614 @default.
- W3096064145 doi "https://doi.org/10.7554/elife.61312" @default.
- W3096064145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7723407" @default.
- W3096064145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33112236" @default.
- W3096064145 hasPublicationYear "2020" @default.
- W3096064145 type Work @default.
- W3096064145 sameAs 3096064145 @default.
- W3096064145 citedByCount "1164" @default.
- W3096064145 countsByYear W30960641452020 @default.
- W3096064145 countsByYear W30960641452021 @default.
- W3096064145 countsByYear W30960641452022 @default.
- W3096064145 countsByYear W30960641452023 @default.
- W3096064145 crossrefType "journal-article" @default.
- W3096064145 hasAuthorship W3096064145A5001960560 @default.
- W3096064145 hasAuthorship W3096064145A5003699560 @default.
- W3096064145 hasAuthorship W3096064145A5015157595 @default.
- W3096064145 hasAuthorship W3096064145A5017806204 @default.
- W3096064145 hasAuthorship W3096064145A5019683467 @default.
- W3096064145 hasAuthorship W3096064145A5025789964 @default.
- W3096064145 hasAuthorship W3096064145A5026966580 @default.
- W3096064145 hasAuthorship W3096064145A5027633474 @default.
- W3096064145 hasAuthorship W3096064145A5036306540 @default.
- W3096064145 hasAuthorship W3096064145A5036442748 @default.