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- W3096071569 abstract "<b><i>Background:</i></b> Previous studies have indicated that Sirtuin 1 (Sirt1) plays an important role in suppressing inflammatory responses in many diseases. However, the Sirt1 levels and role of Sirt1 in ocular Behçet’s disease (OBD) have not been fully elucidated. <b><i>Objective:</i></b> The objective of this study was to investigate the role of Sirt1 in the pathogenesis of OBD. <b><i>Methods:</i></b> Sirt1 and cytokine levels were measured using ELISA. Cell viability was determined using the Cell Counting Kit-8. The frequencies of Th17 and Th22 cells were detected using flow cytometry. <b><i>Results:</i></b> We found decreased expression of Sirt1 in CD4<sup>+</sup> T cells obtained from patients with active OBD. SRT1720, an agonist of Sirt1, significantly upregulated Sirt1 expression in CD4<sup>+</sup> T cells from patients with active OBD. Sirt1 activation by SRT1720 significantly suppressed the production of interleukin (IL)-17 and IL-22 by CD4<sup>+</sup> T cells and inhibited the expansion of Th17 and Th22 cells. <b><i>Conclusion:</i></b> Our results suggest that decreased Sirt1 expression might be involved in the pathogenesis of OBD and that activation of Sirt1 might be considered a potential target for OBD." @default.
- W3096071569 created "2020-11-09" @default.
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- W3096071569 date "2020-11-03" @default.
- W3096071569 modified "2023-10-16" @default.
- W3096071569 title "Decreased Expression of Sirt1 Contributes to Ocular Behçet’s Disease Progression via Th17 and Th22 Response" @default.
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- W3096071569 doi "https://doi.org/10.1159/000512754" @default.
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