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- W3096080212 abstract "ABSTRACT RLRs sense cytosolic non-self RNAs including viral RNAs before mounting a response leading to the activation of Type-I IFNs. Here, we identify a previously unknown regulation of Snail, a transcription regulator known in EMT, during RNA viral infections and describe its possible implication. RNA viral infections, poly (I:C) transfection and ectopic expression of RLR components activated Snail and Slug in epithelial cells. Detailed examination revealed that MAVS and phosphorylated IRF3 are essential in this regulation. We identified two ISREs in SNAI1 promoter region and their alterations rendered the promoter non-responsive to phospho-IRF3 in luciferase assay. Ectopic expression of Snail and Slug activated RLR pathway and dramatically limited RNA viral infections in epithelial cells pointing to their antiviral functions. Thus, Snail and Slug are transcriptionally regulated by RLRs in a similar manner as IFN-β and they in turn promote RLR pathway possibly strengthening the antiviral state in the cell." @default.
- W3096080212 created "2020-11-09" @default.
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- W3096080212 date "2020-10-27" @default.
- W3096080212 modified "2023-09-23" @default.
- W3096080212 title "Retinoic Acid Inducible Gene-I like Receptors Activate Snail and Slug to Limit RNA Viral Infections" @default.
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- W3096080212 doi "https://doi.org/10.1101/2020.10.27.357509" @default.
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