Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096119033> ?p ?o ?g. }
- W3096119033 abstract "Abstract Mood disorders (MD) are a major burden on society as their biology remains poorly understood, challenging both diagnosis and therapy. Among many observed biological dysfunctions, homeostatic dysregulation, such as metabolic syndrome (MeS), shows considerable comorbidity with MD. Recently, CREB-regulated transcription coactivator 1 (CRTC1), a regulator of brain metabolism, was proposed as a promising factor to understand this relationship. Searching for imaging biomarkers and associating them with pathophysiological mechanisms using preclinical models, can provide significant insight into these complex psychiatric diseases and help the development of personalized healthcare. Here, we used neuroimaging technologies to show that deletion of Crtc1 in mice leads to an imaging fingerprint of hippocampal metabolic impairment related to depressive-like behavior. By identifying the underlying molecular/physiological origin, we could assign an energy-boosting mood-stabilizing treatment, ebselen, which rescued behavior and neuroimaging markers. Finally, our results point towards the GABAergic system as a potential therapeutic target for behavioral dysfunctions related to metabolic disorders. This study provides new insights on Crtc1’s and MeS’s relationship to MD and establishes depression-related markers with clinical potential." @default.
- W3096119033 created "2020-11-09" @default.
- W3096119033 creator A5000881497 @default.
- W3096119033 creator A5010689458 @default.
- W3096119033 creator A5011059352 @default.
- W3096119033 creator A5016324798 @default.
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- W3096119033 creator A5029409294 @default.
- W3096119033 creator A5030928097 @default.
- W3096119033 creator A5036484661 @default.
- W3096119033 date "2020-11-05" @default.
- W3096119033 modified "2023-10-03" @default.
- W3096119033 title "Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior" @default.
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