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- W3096127929 endingPage "105287" @default.
- W3096127929 startingPage "105287" @default.
- W3096127929 abstract "Resveratrol, trans 3,5,4′-trihydroxystilbene, is a stilbenoid polyphenol with a wide range of properties including antioxidant, neuroprotective, cardioprotective, anti-inflammatory and anticancer activities. It is found in the skins of grape (50–100 μg/mL), red wine, peanuts, bilberries, blueberries and cranberries. The most important effects of resveratrol have been found in cardiovascular disease, with pulmonary arterial hypertension (PAH) being a major severe and progressive component. Many factors are involved in the pathogenesis of PAH, including enzymes, transcription factors, proteins, chemokines, cytokines, hypoxia, oxidative stress and others. Resveratrol treats PAH through its actions on various signaling pathways. These signaling pathways are mainly suppressed SphK1-mediated NF-κB activation, BMP/SMAD signaling pathway, miR-638 and NR4A3/cyclin D1 pathway, SIRT1 pathway, Nrf-2, HIF-1 α expression, MAPK/ERK1 and PI3K/AKT pathways, and RhoA-ROCK signaling pathway. Resveratrol efficiently inhibits the proliferation of pulmonary arterial smooth muscle cells and right ventricular remodeling, which are underlying processes leading to enhanced PAH. While supportive evidence from randomized controlled trials is yet to be available, current in vitro and in vivo studies seem to be convincing and suggest a therapeutic promise for the use of resveratrol in PAH." @default.
- W3096127929 created "2020-11-09" @default.
- W3096127929 creator A5031560022 @default.
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- W3096127929 creator A5046431472 @default.
- W3096127929 creator A5083099452 @default.
- W3096127929 creator A5084551363 @default.
- W3096127929 date "2021-01-01" @default.
- W3096127929 modified "2023-10-17" @default.
- W3096127929 title "Resveratrol: Mechanistic and therapeutic perspectives in pulmonary arterial hypertension" @default.
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