FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096179219> ?p ?o ?g. }

• W3096179219 abstract "Abstract Copper is a crucial trace element for all living systems and any deficiency in copper homeostasis leads to the development of severe diseases in humans. The observation of extensive evolutionary conservation in copper homeostatic systems between human and Saccharomyces cerevisiae made this organism a suitable model organism for elucidating molecular mechanisms of copper transport and homeostasis. In this study, the dynamic transcriptional response of both the reference strain and homozygous deletion mutant strain of CCC2 , which encodes a Cu 2+ -transporting P-type ATPase, were investigated following the introduction of copper impulse to reach a copper concentration which was shown to improve the respiration capacity of CCC2 deletion mutants. The analysis of data by using different clustering algorithms revealed significantly affected processes and pathways in response to a switch from copper deficient environment to elevated copper levels. Sulfur compound, methionine and cysteine biosynthetic processes were identified as significantly affected processes for the first time in this study. Stress response, cellular response to DNA damage, iron ion homeostasis, ubiquitin dependent proteolysis, autophagy and regulation of macroautophagy, DNA repair and replication, as well as organization of mitochondrial respiratory chain complex IV, mitochondrial organization and translation were identified as significantly affected processes in only CCC2 deleted strain. The integration of the transcriptomic data with regulome revealed the differences in the extensive re-wiring of dynamic transcriptional organization and regulation in these strains." @default.
• W3096179219 created "2020-11-09" @default.
• W3096179219 creator A5048119209 @default.
• W3096179219 creator A5052840986 @default.
• W3096179219 creator A5073030434 @default.
• W3096179219 date "2020-10-28" @default.
• W3096179219 modified "2023-09-26" @default.
• W3096179219 title "Dynamic transcriptional response of Saccharomyces cerevisiae cells to copper" @default.
• W3096179219 cites W1478988028 @default.
• W3096179219 cites W1514437369 @default.
• W3096179219 cites W1527489814 @default.
• W3096179219 cites W1573826674 @default.
• W3096179219 cites W1644724366 @default.
• W3096179219 cites W1696228719 @default.
• W3096179219 cites W1963874808 @default.
• W3096179219 cites W1966327575 @default.
• W3096179219 cites W1974359567 @default.
• W3096179219 cites W1975952108 @default.
• W3096179219 cites W1991020250 @default.
• W3096179219 cites W2001314904 @default.
• W3096179219 cites W2003982140 @default.
• W3096179219 cites W2008618177 @default.
• W3096179219 cites W2010232053 @default.
• W3096179219 cites W2011444292 @default.
• W3096179219 cites W2020582877 @default.
• W3096179219 cites W2027287962 @default.
• W3096179219 cites W2038437697 @default.
• W3096179219 cites W2042798506 @default.
• W3096179219 cites W2047390883 @default.
• W3096179219 cites W2047668666 @default.
• W3096179219 cites W2049849193 @default.
• W3096179219 cites W2052607444 @default.
• W3096179219 cites W2053207061 @default.
• W3096179219 cites W2065243723 @default.
• W3096179219 cites W2087813537 @default.
• W3096179219 cites W2087946910 @default.
• W3096179219 cites W2099118166 @default.
• W3096179219 cites W2099429838 @default.
• W3096179219 cites W2101142880 @default.
• W3096179219 cites W2107071733 @default.
• W3096179219 cites W2109972881 @default.
• W3096179219 cites W2114848685 @default.
• W3096179219 cites W2137771214 @default.
• W3096179219 cites W2149566602 @default.
• W3096179219 cites W2153287706 @default.
• W3096179219 cites W2158217645 @default.
• W3096179219 cites W2159517143 @default.
• W3096179219 cites W2159675211 @default.
• W3096179219 cites W2162891889 @default.
• W3096179219 cites W2163350914 @default.
• W3096179219 cites W2165133998 @default.
• W3096179219 cites W2167450976 @default.
• W3096179219 cites W2171030481 @default.
• W3096179219 cites W2172556041 @default.
• W3096179219 cites W2223070071 @default.
• W3096179219 cites W2230074349 @default.
• W3096179219 cites W2268730793 @default.
• W3096179219 cites W2288638618 @default.
• W3096179219 cites W2325677561 @default.
• W3096179219 cites W2472624160 @default.
• W3096179219 cites W2474986042 @default.
• W3096179219 cites W2561135783 @default.
• W3096179219 cites W2752111317 @default.
• W3096179219 cites W2789725996 @default.
• W3096179219 cites W2791565546 @default.
• W3096179219 cites W4211242412 @default.
• W3096179219 cites W4294216483 @default.
• W3096179219 cites W45534775 @default.
• W3096179219 doi "https://doi.org/10.1038/s41598-020-75511-w" @default.
• W3096179219 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7595141" @default.
• W3096179219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33116258" @default.
• W3096179219 hasPublicationYear "2020" @default.
• W3096179219 type Work @default.
• W3096179219 sameAs 3096179219 @default.
• W3096179219 citedByCount "7" @default.
• W3096179219 countsByYear W30961792192021 @default.
• W3096179219 countsByYear W30961792192022 @default.
• W3096179219 countsByYear W30961792192023 @default.
• W3096179219 crossrefType "journal-article" @default.
• W3096179219 hasAuthorship W3096179219A5048119209 @default.
• W3096179219 hasAuthorship W3096179219A5052840986 @default.
• W3096179219 hasAuthorship W3096179219A5073030434 @default.
• W3096179219 hasBestOaLocation W30961792191 @default.
• W3096179219 hasConcept C104317684 @default.
• W3096179219 hasConcept C143065580 @default.
• W3096179219 hasConcept C143425029 @default.
• W3096179219 hasConcept C150194340 @default.
• W3096179219 hasConcept C162317418 @default.
• W3096179219 hasConcept C178790620 @default.
• W3096179219 hasConcept C185592680 @default.
• W3096179219 hasConcept C190283241 @default.
• W3096179219 hasConcept C19843653 @default.
• W3096179219 hasConcept C203522944 @default.
• W3096179219 hasConcept C2777106986 @default.
• W3096179219 hasConcept C2777576037 @default.
• W3096179219 hasConcept C54355233 @default.
• W3096179219 hasConcept C544778455 @default.
• W3096179219 hasConcept C552990157 @default.
• W3096179219 hasConcept C55493867 @default.
• W3096179219 hasConcept C63645605 @default.

• next