Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096197860> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W3096197860 abstract "Introduction: BMS-986278 is being investigated as a treatment (tx) for idiopathic pulmonary fibrosis (IPF). In vitro studies demonstrated that OATP mediates human hepatic uptake of BMS-986278. Patients with IPF often receive concomitant medications, including OATPi. Aims and Objectives: To evaluate the effects of rifampin (rif) on the PK and tolerability of BMS-986278 in healthy adult participants (ppts). Methods: This was an open-label drug-interaction study. Fasted ppts received an oral dose of 30 mg BMS-986278 on d1 followed by a 7-d washout; on d8, ppts received an oral dose of 600 mg rif and 30 mg BMS-986278. Plasma PK was measured for BMS-986278 and rif; tolerability was monitored. Results: All 15 enrolled ppts completed the study (73% male, 73% white, mean [SD] age 46.1 [12.7] y and BMI 25.2 [2.7] kg/m2). Following coadministration with rif, BMS-986278 mean area under the curve from 0 to infinity (AUC0-inf) and maximum concentration (Cmax) were elevated by 3.13- and 2.75-fold, respectively, vs BMS-986278 alone. Median time to Cmax (Tmax) increased from 1.1 h (BMS-986278) to 2.0 h (BMS-986278+rif). Rif PK matched published data. BMS-986278+rif and BMS-986278 alone demonstrated a similar safety profile. Of 4 reported adverse events, 3 were mild (back pain, nausea, and presyncope) and 1 was moderate (constipation); none were deemed related to tx. Conclusions: BMS-986278+rif and BMS-986278 alone were generally well tolerated; increases in exposure up to 3x of BMS-986278 were observed with co-administration of rif. Concomitant OATPi medications anticipated to increase BMS-986278 exposure" @default.
- W3096197860 created "2020-11-09" @default.
- W3096197860 creator A5020783463 @default.
- W3096197860 creator A5043754532 @default.
- W3096197860 creator A5044159184 @default.
- W3096197860 creator A5053284695 @default.
- W3096197860 creator A5054943327 @default.
- W3096197860 creator A5073524871 @default.
- W3096197860 date "2020-09-07" @default.
- W3096197860 modified "2023-10-01" @default.
- W3096197860 title "Effect of rifampin, a potent organic-anion-transporting polypeptide inhibitor (OATPi), on the PK of BMS-986278, a lysophosphatidic acid receptor (LPA1) antagonist" @default.
- W3096197860 doi "https://doi.org/10.1183/13993003.congress-2020.3495" @default.
- W3096197860 hasPublicationYear "2020" @default.
- W3096197860 type Work @default.
- W3096197860 sameAs 3096197860 @default.
- W3096197860 citedByCount "0" @default.
- W3096197860 crossrefType "proceedings-article" @default.
- W3096197860 hasAuthorship W3096197860A5020783463 @default.
- W3096197860 hasAuthorship W3096197860A5043754532 @default.
- W3096197860 hasAuthorship W3096197860A5044159184 @default.
- W3096197860 hasAuthorship W3096197860A5053284695 @default.
- W3096197860 hasAuthorship W3096197860A5054943327 @default.
- W3096197860 hasAuthorship W3096197860A5073524871 @default.
- W3096197860 hasConcept C112705442 @default.
- W3096197860 hasConcept C126322002 @default.
- W3096197860 hasConcept C197934379 @default.
- W3096197860 hasConcept C22979827 @default.
- W3096197860 hasConcept C2778375690 @default.
- W3096197860 hasConcept C2779384505 @default.
- W3096197860 hasConcept C2780580376 @default.
- W3096197860 hasConcept C71924100 @default.
- W3096197860 hasConcept C90924648 @default.
- W3096197860 hasConcept C98274493 @default.
- W3096197860 hasConceptScore W3096197860C112705442 @default.
- W3096197860 hasConceptScore W3096197860C126322002 @default.
- W3096197860 hasConceptScore W3096197860C197934379 @default.
- W3096197860 hasConceptScore W3096197860C22979827 @default.
- W3096197860 hasConceptScore W3096197860C2778375690 @default.
- W3096197860 hasConceptScore W3096197860C2779384505 @default.
- W3096197860 hasConceptScore W3096197860C2780580376 @default.
- W3096197860 hasConceptScore W3096197860C71924100 @default.
- W3096197860 hasConceptScore W3096197860C90924648 @default.
- W3096197860 hasConceptScore W3096197860C98274493 @default.
- W3096197860 hasLocation W30961978601 @default.
- W3096197860 hasOpenAccess W3096197860 @default.
- W3096197860 hasPrimaryLocation W30961978601 @default.
- W3096197860 hasRelatedWork W11032860 @default.
- W3096197860 hasRelatedWork W14180436 @default.
- W3096197860 hasRelatedWork W15036479 @default.
- W3096197860 hasRelatedWork W16161069 @default.
- W3096197860 hasRelatedWork W18996837 @default.
- W3096197860 hasRelatedWork W3643340 @default.
- W3096197860 hasRelatedWork W4081904 @default.
- W3096197860 hasRelatedWork W4454111 @default.
- W3096197860 hasRelatedWork W6014000 @default.
- W3096197860 hasRelatedWork W7167190 @default.
- W3096197860 isParatext "false" @default.
- W3096197860 isRetracted "false" @default.
- W3096197860 magId "3096197860" @default.
- W3096197860 workType "article" @default.