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- W3096224719 abstract "RET (REarranged during Transfection)is activated by DNA rearrangement of the 3' fragment of the receptor tyrosine kinase gene, namely, RET proto-oncogene, with the 5' fragment of various genes with putative dimerization domains, such as a coiled coil domain, that are necessary for constitutive activation. RET rearrangements have been detected in a variety of human cancers, including thyroid, lung, colorectal, breast, and salivary gland cancers. Moreover, point mutations in RET are responsible for multiple endocrine neoplasia types 2A and 2B, which can develop into medullary thyroid cancer and pheochromocytoma. Substantial effort is currently being exerted in developing RET kinase inhibitors. RET is also responsible for Hirschsprung's disease, a developmental abnormality in the enteric nervous system. Gene knockout studies have demonstrated that RET plays essential roles in the development of the enteric nervous system and kidney as well as in spermatogenesis. Studies regarding RET continue to provide fascinating challenges in the fields of cancer research, neuroscience, and developmental biology." @default.
- W3096224719 created "2020-11-09" @default.
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- W3096224719 date "2020-01-01" @default.
- W3096224719 modified "2023-10-10" @default.
- W3096224719 title "Roles of the <i>RET</i> Proto-oncogene in Cancer and Development" @default.
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- W3096224719 cites W1601190908 @default.
- W3096224719 cites W1875361486 @default.
- W3096224719 cites W1964893667 @default.
- W3096224719 cites W1971208141 @default.
- W3096224719 cites W1979188008 @default.
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- W3096224719 cites W2014078232 @default.
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- W3096224719 doi "https://doi.org/10.31662/jmaj.2020-0021" @default.
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