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- W3096229610 endingPage "522" @default.
- W3096229610 startingPage "503" @default.
- W3096229610 abstract "Epithelial ovarian cancer involves the shedding of single tumor cells or spheroids from the primary tumor into ascites, followed by their survival, and transit to the sites of metastatic colonization within the peritoneal cavity. During their flotation, anchorage-dependent epithelial-type tumor cells gain anoikis resistance, implicating integrins, including αvß3. In this study, we explored anoikis escape, cisplatin resistance, and prosurvival signaling as a function of the αvß3 transmembrane conformational activation state in cells suspended in ascites. A high-affinity and constitutively signaling-competent αvß3 variant, which harbored unclasped transmembrane domains, was found to confer delayed anoikis onset, enhanced cisplatin resistance, and reduced cell proliferation in ascites or 3D-hydrogels, involving p27kip upregulation. Moreover, it promoted EGF-R expression and activation, prosurvival signaling, implicating FAK, src, and PKB/Akt. This led to the induction of the anti-apoptotic factors Bcl-2 and survivin suppressing caspase activation, compared to a signaling-incapable αvß3 variant displaying firmly associated transmembrane domains. Dissecting the mechanistic players for αvß3-dependent survival and peritoneal metastasis of ascitic ovarian cancer spheroids is of paramount importance to target their anchorage independence by reversing anoikis resistance and blocking αvß3-triggered prosurvival signaling." @default.
- W3096229610 created "2020-11-09" @default.
- W3096229610 creator A5016588232 @default.
- W3096229610 creator A5017448580 @default.
- W3096229610 creator A5020575310 @default.
- W3096229610 creator A5022140307 @default.
- W3096229610 creator A5037055195 @default.
- W3096229610 creator A5051963112 @default.
- W3096229610 creator A5075901741 @default.
- W3096229610 creator A5083769382 @default.
- W3096229610 date "2020-12-01" @default.
- W3096229610 modified "2023-10-17" @default.
- W3096229610 title "Constitutive activation of integrin αvβ3 contributes to anoikis resistance of ovarian cancer cells" @default.
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