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- W3096275547 abstract "Copper nanoclusters (CuNCs) are emerging as an interesting class of materials for various biomedical applications. In this work, we have designed highly stable nucleobase-capped luminescent CuNCs and studied the effect of substituents on the cluster composition and photophysical properties. The NCs exhibit exceptional stability in ambient atmosphere and show significant variation in the emission properties with a change in position of substituents on the ligand, thiouracil. This study represents the first example of a nanocluster that functionally mimics the activity of a major antioxidant enzyme, superoxide dismutase (SOD). In addition to their enzyme-mimetic activity, the CuNCs evince controlled release of nitric oxide (NO), a key gaseous molecule of endothelial system from S-nitrosothiol, S-nitrosoglutathione (GSNO). Further, to a greater significance, these luminescent CuNCs are readily taken up by the mammalian cells and exhibit low toxicity. The superoxide dismutase and NO releasing activity of the fluorescent, biocompatible copper nanoclusters suggest their potential application in both therapeutics and bioimaging." @default.
- W3096275547 created "2020-11-09" @default.
- W3096275547 creator A5008583537 @default.
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- W3096275547 date "2020-11-04" @default.
- W3096275547 modified "2023-10-17" @default.
- W3096275547 title "Highly Stable Pyrimidine Based Luminescent Copper Nanoclusters with Superoxide Dismutase Mimetic and Nitric Oxide Releasing Activity" @default.
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- W3096275547 doi "https://doi.org/10.1021/acsabm.0c00675" @default.
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- W3096275547 hasPublicationYear "2020" @default.
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