Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096304003> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W3096304003 endingPage "2845" @default.
- W3096304003 startingPage "2839" @default.
- W3096304003 abstract "A quantitative structure activity relationship (QSAR) analysis was performed on several compound and aurone derivatives (1-16) and 17-21 compounds were used as internal and external tests, respectively. Studies have investigated aurone derivatives; however, for aurone compounds, QSAR analysis has not been conducted. The semi-empirical PM3 method of HyperChem for Windows 8.0 was used to optimise the aurone derivative structures to acquire descriptors. For 15 influential descriptors, the multilinear regression MLR analysis was conducted by employing the backward method, and four new QSAR models were obtained. According to statistical criteria, model 2 was the optimum QSAR model for predicting the inhibition concentration (IC50) theoretical value against novel aurone derivatives. The modelling of 40 (22-61) aurone compounds was achieved. Six novel compounds (54, 55, 58, 59, 60, and 61) were synthesized in a laboratory because the IC50 of these compounds was lower than that of chloroquine (IC50 = 0.14 μM)." @default.
- W3096304003 created "2020-11-09" @default.
- W3096304003 creator A5055820068 @default.
- W3096304003 date "2020-01-01" @default.
- W3096304003 modified "2023-10-16" @default.
- W3096304003 title "A QSAR Modeling on Aurone Derivatives as Antimalarial Agents" @default.
- W3096304003 cites W1749897720 @default.
- W3096304003 cites W1967124792 @default.
- W3096304003 cites W1978767347 @default.
- W3096304003 cites W1998687048 @default.
- W3096304003 cites W1998853975 @default.
- W3096304003 cites W2069243241 @default.
- W3096304003 cites W2086190989 @default.
- W3096304003 cites W2099960658 @default.
- W3096304003 cites W2114649299 @default.
- W3096304003 cites W2147326794 @default.
- W3096304003 cites W2291465655 @default.
- W3096304003 cites W2665522230 @default.
- W3096304003 cites W2748469774 @default.
- W3096304003 cites W2770479784 @default.
- W3096304003 cites W2775204735 @default.
- W3096304003 cites W2775561916 @default.
- W3096304003 cites W2780107531 @default.
- W3096304003 cites W2788556251 @default.
- W3096304003 cites W2791962874 @default.
- W3096304003 cites W2805597404 @default.
- W3096304003 cites W2806631171 @default.
- W3096304003 cites W2807070489 @default.
- W3096304003 cites W2890950141 @default.
- W3096304003 cites W2892163055 @default.
- W3096304003 cites W2896703696 @default.
- W3096304003 cites W3015874439 @default.
- W3096304003 cites W4210545875 @default.
- W3096304003 doi "https://doi.org/10.14233/ajchem.2020.22846" @default.
- W3096304003 hasPublicationYear "2020" @default.
- W3096304003 type Work @default.
- W3096304003 sameAs 3096304003 @default.
- W3096304003 citedByCount "0" @default.
- W3096304003 crossrefType "journal-article" @default.
- W3096304003 hasAuthorship W3096304003A5055820068 @default.
- W3096304003 hasBestOaLocation W30963040031 @default.
- W3096304003 hasConcept C119857082 @default.
- W3096304003 hasConcept C164126121 @default.
- W3096304003 hasConcept C185592680 @default.
- W3096304003 hasConcept C202444582 @default.
- W3096304003 hasConcept C21951064 @default.
- W3096304003 hasConcept C33923547 @default.
- W3096304003 hasConcept C41008148 @default.
- W3096304003 hasConcept C48921125 @default.
- W3096304003 hasConcept C71240020 @default.
- W3096304003 hasConcept C84392682 @default.
- W3096304003 hasConceptScore W3096304003C119857082 @default.
- W3096304003 hasConceptScore W3096304003C164126121 @default.
- W3096304003 hasConceptScore W3096304003C185592680 @default.
- W3096304003 hasConceptScore W3096304003C202444582 @default.
- W3096304003 hasConceptScore W3096304003C21951064 @default.
- W3096304003 hasConceptScore W3096304003C33923547 @default.
- W3096304003 hasConceptScore W3096304003C41008148 @default.
- W3096304003 hasConceptScore W3096304003C48921125 @default.
- W3096304003 hasConceptScore W3096304003C71240020 @default.
- W3096304003 hasConceptScore W3096304003C84392682 @default.
- W3096304003 hasIssue "11" @default.
- W3096304003 hasLocation W30963040031 @default.
- W3096304003 hasOpenAccess W3096304003 @default.
- W3096304003 hasPrimaryLocation W30963040031 @default.
- W3096304003 hasRelatedWork W1984214777 @default.
- W3096304003 hasRelatedWork W2002100157 @default.
- W3096304003 hasRelatedWork W2024143080 @default.
- W3096304003 hasRelatedWork W2029009136 @default.
- W3096304003 hasRelatedWork W2080583145 @default.
- W3096304003 hasRelatedWork W2101271139 @default.
- W3096304003 hasRelatedWork W2333693818 @default.
- W3096304003 hasRelatedWork W2347231435 @default.
- W3096304003 hasRelatedWork W3198348684 @default.
- W3096304003 hasRelatedWork W4247494091 @default.
- W3096304003 hasVolume "32" @default.
- W3096304003 isParatext "false" @default.
- W3096304003 isRetracted "false" @default.
- W3096304003 magId "3096304003" @default.
- W3096304003 workType "article" @default.