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- W3096322080 abstract "Spatial changes of FAs in the retina in response to different dietary n-3 formulations have never been explored, although a diet rich in EPA and DHA is recommended to protect the retina against the effects of aging. In this study, Wistar rats were fed for 8 weeks with balanced diet including either EPA-containing phospholipids (PLs), EPA-containing TGs, DHA-containing PLs, or DHA-containing TGs. Qualitative changes in FA composition of plasma, erythrocytes, and retina were evaluated by gas chromatography-flame ionization detector. Following the different dietary intakes, changes to the quantity and spatial organization of PC and PE species in retina were determined by LC coupled to MS/MS and MALDI coupled to MS imaging. The omega-3 content in the lipids of plasma and erythrocytes suggests that PLs as well as TGs are good omega-3 carriers for retina. However, a significant increase in DHA content in retina was observed, especially molecular species as di-DHA-containing PC and PE, as well as an increase in very long chain PUFAs (more than 28 carbons) following PL-EPA and TG-DHA diets only. All supplemented diets triggered spatial organization changes of DHA in the photoreceptor layer around the optic nerve. Taken together, these findings suggest that dietary omega-3 supplementation can modify the content of FAs in the rat retina." @default.
- W3096322080 created "2020-11-09" @default.
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- W3096322080 date "2020-12-01" @default.
- W3096322080 modified "2023-10-14" @default.
- W3096322080 title "Bioavailability and spatial distribution of fatty acids in the rat retina after dietary omega-3 supplementation" @default.
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- W3096322080 doi "https://doi.org/10.1194/jlr.ra120001057" @default.
- W3096322080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7707163" @default.
- W3096322080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33531250" @default.
- W3096322080 hasPublicationYear "2020" @default.
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