FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096329686> ?p ?o ?g. }

• W3096329686 endingPage "112991" @default.
• W3096329686 startingPage "112991" @default.
• W3096329686 abstract "Fungal infections have become a serious medical problem due to the high infection rate and the frequent emergence of drug resistance. Squalene epoxidase (SE) and 14α-demethylase (CYP51) are considered as the important antifungal targets, they can show the synergistic effect on antifungal therapy. In the study, a series of active fragments were screened through the method of De Novo Link, and these active fragments with the higher Ludi_Scores were selected, which can show the obvious binding ability with the dual targets (SE, CYP51). Subsequently, three series of target compounds with naphthyl amide scaffolds were constructed by connecting these core fragments, and their structures were synthesized. Most of compounds showed the antifungal activity in the treatment of pathogenic fungi. It was worth noting that compounds 10b-5 and 17a-2 with the excellent broad-spectrum antifungal properties also exhibited the obvious antifungal effects against drug-resistant fungi. Preliminary mechanism study has proved these target compounds can block the biosynthesis of ergosterol by inhibiting the activity of dual targets (SE, CYP51). Furthermore, target compounds 10–5 and 17a-2 with low toxicity side effects also demonstrated the excellent pharmacological effects in vivo. The molecular docking and ADMET prediction were performed, which can guide the optimization of subsequent lead compounds." @default.
• W3096329686 created "2020-11-09" @default.
• W3096329686 creator A5008742216 @default.
• W3096329686 creator A5019988338 @default.
• W3096329686 creator A5042152032 @default.
• W3096329686 creator A5059844255 @default.
• W3096329686 creator A5063575227 @default.
• W3096329686 creator A5077624972 @default.
• W3096329686 date "2021-01-01" @default.
• W3096329686 modified "2023-10-14" @default.
• W3096329686 title "Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation" @default.
• W3096329686 cites W1985953075 @default.
• W3096329686 cites W1997245818 @default.
• W3096329686 cites W2003564377 @default.
• W3096329686 cites W2009920744 @default.
• W3096329686 cites W2010857942 @default.
• W3096329686 cites W2013470980 @default.
• W3096329686 cites W2013516404 @default.
• W3096329686 cites W2014188602 @default.
• W3096329686 cites W2032247464 @default.
• W3096329686 cites W2037736620 @default.
• W3096329686 cites W2075093963 @default.
• W3096329686 cites W2094834649 @default.
• W3096329686 cites W2114409750 @default.
• W3096329686 cites W2129227816 @default.
• W3096329686 cites W2135182325 @default.
• W3096329686 cites W2170048458 @default.
• W3096329686 cites W2485803280 @default.
• W3096329686 cites W2496319682 @default.
• W3096329686 cites W2551752066 @default.
• W3096329686 cites W2558180179 @default.
• W3096329686 cites W2593598577 @default.
• W3096329686 cites W2610314569 @default.
• W3096329686 cites W2612278270 @default.
• W3096329686 cites W2619196045 @default.
• W3096329686 cites W2741785456 @default.
• W3096329686 cites W2750959598 @default.
• W3096329686 cites W2786847658 @default.
• W3096329686 cites W2794593110 @default.
• W3096329686 cites W2804572516 @default.
• W3096329686 cites W2806851786 @default.
• W3096329686 cites W2899503880 @default.
• W3096329686 cites W2906159259 @default.
• W3096329686 cites W2914478931 @default.
• W3096329686 cites W2946254796 @default.
• W3096329686 cites W2951290596 @default.
• W3096329686 cites W2951534921 @default.
• W3096329686 cites W2956150907 @default.
• W3096329686 cites W2961241773 @default.
• W3096329686 cites W2969818513 @default.
• W3096329686 cites W3010943216 @default.
• W3096329686 cites W3020024279 @default.
• W3096329686 cites W3024520663 @default.
• W3096329686 cites W3043208009 @default.
• W3096329686 cites W3045708299 @default.
• W3096329686 doi "https://doi.org/10.1016/j.ejmech.2020.112991" @default.
• W3096329686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33183866" @default.
• W3096329686 hasPublicationYear "2021" @default.
• W3096329686 type Work @default.
• W3096329686 sameAs 3096329686 @default.
• W3096329686 citedByCount "21" @default.
• W3096329686 countsByYear W30963296862021 @default.
• W3096329686 countsByYear W30963296862022 @default.
• W3096329686 countsByYear W30963296862023 @default.
• W3096329686 crossrefType "journal-article" @default.
• W3096329686 hasAuthorship W3096329686A5008742216 @default.
• W3096329686 hasAuthorship W3096329686A5019988338 @default.
• W3096329686 hasAuthorship W3096329686A5042152032 @default.
• W3096329686 hasAuthorship W3096329686A5059844255 @default.
• W3096329686 hasAuthorship W3096329686A5063575227 @default.
• W3096329686 hasAuthorship W3096329686A5077624972 @default.
• W3096329686 hasConcept C150903083 @default.
• W3096329686 hasConcept C159110408 @default.
• W3096329686 hasConcept C185592680 @default.
• W3096329686 hasConcept C202751555 @default.
• W3096329686 hasConcept C207001950 @default.
• W3096329686 hasConcept C21951064 @default.
• W3096329686 hasConcept C2777752112 @default.
• W3096329686 hasConcept C2777910421 @default.
• W3096329686 hasConcept C2778439535 @default.
• W3096329686 hasConcept C2779548794 @default.
• W3096329686 hasConcept C2780035454 @default.
• W3096329686 hasConcept C2780651595 @default.
• W3096329686 hasConcept C41685203 @default.
• W3096329686 hasConcept C55493867 @default.
• W3096329686 hasConcept C71240020 @default.
• W3096329686 hasConcept C71924100 @default.
• W3096329686 hasConcept C86803240 @default.
• W3096329686 hasConcept C89423630 @default.
• W3096329686 hasConcept C98274493 @default.
• W3096329686 hasConceptScore W3096329686C150903083 @default.
• W3096329686 hasConceptScore W3096329686C159110408 @default.
• W3096329686 hasConceptScore W3096329686C185592680 @default.
• W3096329686 hasConceptScore W3096329686C202751555 @default.
• W3096329686 hasConceptScore W3096329686C207001950 @default.
• W3096329686 hasConceptScore W3096329686C21951064 @default.
• W3096329686 hasConceptScore W3096329686C2777752112 @default.
• W3096329686 hasConceptScore W3096329686C2777910421 @default.

• next