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- W3096336205 abstract "As one of the most fatal gastrointestinal cancers, pancreatic cancer (PC) has a long-term survival rate that has shown limited improvement during recent decades and remains dismal. The poor prognosis is attributed to challenges in early detection, low opportunity for radical resection and resistance to chemotherapy and radiation. Macrophages are one of the most abundant infiltrating immune cells in PC stroma, and they can crosstalk with cancer cells, adipocytes and other stromal cells to modulate metabolism, inflammation and immune status, create an immunosuppressive tumor microenvironment (TME), and ultimately facilitate tumor initiation and progression. In this review, we summarize recent advances in our understanding of macrophage origin, distribution and polarization, as well as provide a thorough review of the role macrophages in PC carcinogenesis and development, as well as the underlying molecular mechanism. Additionally, we investigated macrophage targets in preclinical and clinical trials to evaluate their potential therapeutic value in PC. • Macrophages play pivotal role in maintaining tissue homeostasis and immune stable. • Crosstalk between macrophages and adipocytes is a key regulator of inflammation, lipid metabolism and immune response. • Tumor associated macrophages (TAMs) promote carcinogenesis and progression of pancreatic cancer via different mechanisms. • Targeting macrophages therapeutics may provide novel treatment strategies for patients with pancreatic cancer." @default.
- W3096336205 created "2020-11-09" @default.
- W3096336205 creator A5011028947 @default.
- W3096336205 creator A5014184851 @default.
- W3096336205 creator A5014616197 @default.
- W3096336205 creator A5055963689 @default.
- W3096336205 date "2021-02-01" @default.
- W3096336205 modified "2023-10-12" @default.
- W3096336205 title "Macrophages in pancreatic cancer: An immunometabolic perspective" @default.
- W3096336205 cites W1551186235 @default.
- W3096336205 cites W1649938880 @default.
- W3096336205 cites W1775874433 @default.
- W3096336205 cites W1858549592 @default.
- W3096336205 cites W1963578712 @default.
- W3096336205 cites W1963895131 @default.
- W3096336205 cites W1964795575 @default.
- W3096336205 cites W1968812902 @default.
- W3096336205 cites W1970539851 @default.
- W3096336205 cites W1970766774 @default.
- W3096336205 cites W1971308765 @default.
- W3096336205 cites W1971620413 @default.
- W3096336205 cites W1975159841 @default.
- W3096336205 cites W1991256742 @default.
- W3096336205 cites W1997944395 @default.
- W3096336205 cites W2002504985 @default.
- W3096336205 cites W2002856180 @default.
- W3096336205 cites W2007663426 @default.
- W3096336205 cites W2009109918 @default.
- W3096336205 cites W2010563204 @default.
- W3096336205 cites W2012063336 @default.
- W3096336205 cites W2019764524 @default.
- W3096336205 cites W2022101765 @default.
- W3096336205 cites W2025381786 @default.
- W3096336205 cites W2026908726 @default.
- W3096336205 cites W2029409898 @default.
- W3096336205 cites W2032131517 @default.
- W3096336205 cites W2032439463 @default.
- W3096336205 cites W2038545166 @default.
- W3096336205 cites W2042435738 @default.
- W3096336205 cites W2043991982 @default.
- W3096336205 cites W2045122835 @default.
- W3096336205 cites W2046547919 @default.
- W3096336205 cites W2046878349 @default.
- W3096336205 cites W2047361362 @default.
- W3096336205 cites W2052821169 @default.
- W3096336205 cites W2055703363 @default.
- W3096336205 cites W2055933911 @default.
- W3096336205 cites W2057106552 @default.
- W3096336205 cites W2058528752 @default.
- W3096336205 cites W2058648826 @default.
- W3096336205 cites W2060913247 @default.
- W3096336205 cites W2061294496 @default.
- W3096336205 cites W2061686058 @default.
- W3096336205 cites W2069269337 @default.
- W3096336205 cites W2070085523 @default.
- W3096336205 cites W2070855360 @default.
- W3096336205 cites W2072462631 @default.
- W3096336205 cites W2083370868 @default.
- W3096336205 cites W2083666530 @default.
- W3096336205 cites W2087075862 @default.
- W3096336205 cites W2089431977 @default.
- W3096336205 cites W2089836937 @default.
- W3096336205 cites W2098517576 @default.
- W3096336205 cites W2108775189 @default.
- W3096336205 cites W2111895881 @default.
- W3096336205 cites W2116556497 @default.
- W3096336205 cites W2117692326 @default.
- W3096336205 cites W2119444855 @default.
- W3096336205 cites W2123660912 @default.
- W3096336205 cites W2123937928 @default.
- W3096336205 cites W2129205941 @default.
- W3096336205 cites W2131464730 @default.
- W3096336205 cites W2132132957 @default.
- W3096336205 cites W2138155367 @default.
- W3096336205 cites W2139036573 @default.
- W3096336205 cites W2141189887 @default.
- W3096336205 cites W2144426613 @default.
- W3096336205 cites W2150232019 @default.
- W3096336205 cites W2155892126 @default.
- W3096336205 cites W2158070898 @default.
- W3096336205 cites W2162891726 @default.
- W3096336205 cites W2163175900 @default.
- W3096336205 cites W2163471981 @default.
- W3096336205 cites W2164355096 @default.
- W3096336205 cites W2164664027 @default.
- W3096336205 cites W2166653998 @default.
- W3096336205 cites W2168339950 @default.
- W3096336205 cites W2176476431 @default.
- W3096336205 cites W2191169263 @default.
- W3096336205 cites W2193423443 @default.
- W3096336205 cites W2200997261 @default.
- W3096336205 cites W2202349529 @default.
- W3096336205 cites W2246406150 @default.
- W3096336205 cites W2265800624 @default.
- W3096336205 cites W2276765336 @default.
- W3096336205 cites W2277966485 @default.
- W3096336205 cites W2281741663 @default.
- W3096336205 cites W2295178911 @default.