Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096341310> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W3096341310 abstract "Objective: Transient pressure overload (TPO) elicits stretch-induced myocyte injury in the absence of ischemia or infarction, but the extent to which this is associated with inflammation is unclear. The present study was designed to assess immune activation after TPO in swine and compare the inflammatory cytokine profile to that observed after myocardial infarction (MI). Methods: Swine received a brief infusion of phenylephrine (18 mg/hr iv; 30-60 min) to induce TPO and were studied for 1 hr (n=5), 3 hr (n=6), or 24 hr (n=6) before analysis of myocardial macrophage gene expression (CD68) via qPCR. Serial blood sampling was performed to assess neutrophil and monocyte counts as well as circulating cardiac troponin I (cTnI), IL-6, TNF-α, and CRP. Cytokine levels were compared to those from a separate group (n=5) subjected to a 60 min LAD occlusion to produce MI. Results: TPO increased circulating cTnI (from 20±5 ng/L to 340±58 ng/L at 3 hr and 1520±616 ng/L at 24 hr; p<0.01) without evidence of infarction. Compared with controls (n=6), swine subjected to TPO exhibited increased CD68 gene expression at 1, 3, and 24 hr ( A ). This was accompanied by a rise in peripheral blood neutrophils and monocytes ( B ) as well as an elevation in circulating IL-6, TNF-α, and CRP that was comparable to that observed after MI ( C ). Conclusion: Myocyte injury following TPO elicits mobilization of neutrophils and monocytes and a rise in circulating inflammatory cytokines comparable to that observed after MI. This is accompanied by an increase in cardiac macrophages and may be an important mechanism by which repetitive episodes of TPO lead to interstitial fibrosis and diastolic dysfunction without anatomic hypertrophy." @default.
- W3096341310 created "2020-11-09" @default.
- W3096341310 creator A5000872753 @default.
- W3096341310 creator A5006467882 @default.
- W3096341310 creator A5006852480 @default.
- W3096341310 creator A5021627399 @default.
- W3096341310 creator A5058617556 @default.
- W3096341310 creator A5066710474 @default.
- W3096341310 date "2020-07-31" @default.
- W3096341310 modified "2023-09-27" @default.
- W3096341310 title "Abstract 265: Systemic Inflammation and Cardiac Macrophage Infiltration Accompany Stretch-induced Myocardial Injury in Swine Subjected to Transient Pressure Overload" @default.
- W3096341310 doi "https://doi.org/10.1161/res.127.suppl_1.265" @default.
- W3096341310 hasPublicationYear "2020" @default.
- W3096341310 type Work @default.
- W3096341310 sameAs 3096341310 @default.
- W3096341310 citedByCount "0" @default.
- W3096341310 crossrefType "journal-article" @default.
- W3096341310 hasAuthorship W3096341310A5000872753 @default.
- W3096341310 hasAuthorship W3096341310A5006467882 @default.
- W3096341310 hasAuthorship W3096341310A5006852480 @default.
- W3096341310 hasAuthorship W3096341310A5021627399 @default.
- W3096341310 hasAuthorship W3096341310A5058617556 @default.
- W3096341310 hasAuthorship W3096341310A5066710474 @default.
- W3096341310 hasConcept C115725540 @default.
- W3096341310 hasConcept C126322002 @default.
- W3096341310 hasConcept C134018914 @default.
- W3096341310 hasConcept C164705383 @default.
- W3096341310 hasConcept C17991360 @default.
- W3096341310 hasConcept C207200792 @default.
- W3096341310 hasConcept C2776252253 @default.
- W3096341310 hasConcept C2776914184 @default.
- W3096341310 hasConcept C2778690821 @default.
- W3096341310 hasConcept C2781184567 @default.
- W3096341310 hasConcept C500558357 @default.
- W3096341310 hasConcept C71924100 @default.
- W3096341310 hasConceptScore W3096341310C115725540 @default.
- W3096341310 hasConceptScore W3096341310C126322002 @default.
- W3096341310 hasConceptScore W3096341310C134018914 @default.
- W3096341310 hasConceptScore W3096341310C164705383 @default.
- W3096341310 hasConceptScore W3096341310C17991360 @default.
- W3096341310 hasConceptScore W3096341310C207200792 @default.
- W3096341310 hasConceptScore W3096341310C2776252253 @default.
- W3096341310 hasConceptScore W3096341310C2776914184 @default.
- W3096341310 hasConceptScore W3096341310C2778690821 @default.
- W3096341310 hasConceptScore W3096341310C2781184567 @default.
- W3096341310 hasConceptScore W3096341310C500558357 @default.
- W3096341310 hasConceptScore W3096341310C71924100 @default.
- W3096341310 hasIssue "Suppl_1" @default.
- W3096341310 hasLocation W30963413101 @default.
- W3096341310 hasOpenAccess W3096341310 @default.
- W3096341310 hasPrimaryLocation W30963413101 @default.
- W3096341310 hasRelatedWork W115674540 @default.
- W3096341310 hasRelatedWork W1977918131 @default.
- W3096341310 hasRelatedWork W1990717759 @default.
- W3096341310 hasRelatedWork W2002004883 @default.
- W3096341310 hasRelatedWork W2005546669 @default.
- W3096341310 hasRelatedWork W2034985166 @default.
- W3096341310 hasRelatedWork W2068259322 @default.
- W3096341310 hasRelatedWork W3203913864 @default.
- W3096341310 hasRelatedWork W3208246844 @default.
- W3096341310 hasRelatedWork W4254218321 @default.
- W3096341310 hasVolume "127" @default.
- W3096341310 isParatext "false" @default.
- W3096341310 isRetracted "false" @default.
- W3096341310 magId "3096341310" @default.
- W3096341310 workType "article" @default.