FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096347524> ?p ?o ?g. }

• W3096347524 abstract "Abstract Voriconazole is the first‐line antifungal choice in the treatment of invasive fungal infections (IFIs). Single nucleotide polymorphisms (SNPs) in drug‐metabolizing and transporter genes may affect voriconazole pharmacokinetics. This study aimed to determine the frequency of the CYP2C19 rs4244285, rs4986893, rs72552267, and rs12248560, CYP3A4 rs4646437, ABCB1 rs1045642, and FMO3 rs2266782 alleles and determine the association between these genetic variants and voriconazole concentrations in Thai patients with invasive fungal infections. The study comprised 177 Thai patients with IFIs in whom seven SNPs in CYP2C19 , CYP3A4 , ABCB1, and FMO3 were genotyped using Taq Man real‐time polymerase chain reaction (RT‐PCR) 5´ nuclease assays, and voriconazole plasma concentrations were measured by high‐performance liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). Of the 177 patients included, 31 were <12 years and 146 were ≥12 years. The CYP2C19 allele frequencies were 0.29 for *2 , 0.060 for *3 , 0.003 for *6 , and 0.008 for *17 . The allele frequency of CYP3A4 (rs4646437) was 0.26, ABCB1 (rs1045642) was 0.36, and FMO3 (rs2266782) was 0.16. The median voriconazole dose/weight was significantly lower in patients aged ≥12 years when compared to the patients aged <12 years ( P < .001). Patients aged <12 years with CYP2C19*1/*2 exhibited significantly higher median voriconazole plasma concentrations than those with the CYP2C19*1/*1 ( P = .038). However, there were no significant differences in median voriconazole plasma concentrations among the CYP2C19 genotypes in the patients aged ≥12 years. There was a lack of association observed among the CYP3A4, ABCB1, and FMO3 genotypes on the plasma voriconazole concentrations in both groups of patients. Our findings indicate that voriconazole plasma concentrations are affected by the CYP2C19*2 allele in patients aged <12 years but not in patients aged ≥12 years." @default.
• W3096347524 created "2020-11-09" @default.
• W3096347524 creator A5006547245 @default.
• W3096347524 creator A5012978276 @default.
• W3096347524 creator A5025179298 @default.
• W3096347524 creator A5048561277 @default.
• W3096347524 creator A5070891866 @default.
• W3096347524 creator A5073575196 @default.
• W3096347524 date "2020-10-30" @default.
• W3096347524 modified "2023-10-01" @default.
• W3096347524 title "Impact of <i>CYP2C19</i> , <i>CYP3A4</i> , <i>ABCB1</i> , and <i>FMO3</i> genotypes on plasma voriconazole in Thai patients with invasive fungal infections" @default.
• W3096347524 cites W1484577646 @default.
• W3096347524 cites W1973282809 @default.
• W3096347524 cites W1984588031 @default.
• W3096347524 cites W1996806440 @default.
• W3096347524 cites W2028938803 @default.
• W3096347524 cites W2031785695 @default.
• W3096347524 cites W2031918167 @default.
• W3096347524 cites W2039192679 @default.
• W3096347524 cites W2051816101 @default.
• W3096347524 cites W2057200506 @default.
• W3096347524 cites W2079899732 @default.
• W3096347524 cites W2079989445 @default.
• W3096347524 cites W2083239316 @default.
• W3096347524 cites W2096212756 @default.
• W3096347524 cites W2102806192 @default.
• W3096347524 cites W2103641008 @default.
• W3096347524 cites W2105872820 @default.
• W3096347524 cites W2114643090 @default.
• W3096347524 cites W2145788371 @default.
• W3096347524 cites W2148605276 @default.
• W3096347524 cites W2166478867 @default.
• W3096347524 cites W2235179640 @default.
• W3096347524 cites W2460924175 @default.
• W3096347524 cites W2461860618 @default.
• W3096347524 cites W2562778159 @default.
• W3096347524 cites W2563659108 @default.
• W3096347524 cites W2748580511 @default.
• W3096347524 cites W2756221400 @default.
• W3096347524 cites W2789160819 @default.
• W3096347524 cites W2796455913 @default.
• W3096347524 cites W2808997272 @default.
• W3096347524 cites W2910180756 @default.
• W3096347524 cites W2953306363 @default.
• W3096347524 cites W3025903047 @default.
• W3096347524 cites W4237725196 @default.
• W3096347524 doi "https://doi.org/10.1002/prp2.665" @default.
• W3096347524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7596670" @default.
• W3096347524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33124772" @default.
• W3096347524 hasPublicationYear "2020" @default.
• W3096347524 type Work @default.
• W3096347524 sameAs 3096347524 @default.
• W3096347524 citedByCount "12" @default.
• W3096347524 countsByYear W30963475242021 @default.
• W3096347524 countsByYear W30963475242022 @default.
• W3096347524 countsByYear W30963475242023 @default.
• W3096347524 crossrefType "journal-article" @default.
• W3096347524 hasAuthorship W3096347524A5006547245 @default.
• W3096347524 hasAuthorship W3096347524A5012978276 @default.
• W3096347524 hasAuthorship W3096347524A5025179298 @default.
• W3096347524 hasAuthorship W3096347524A5048561277 @default.
• W3096347524 hasAuthorship W3096347524A5070891866 @default.
• W3096347524 hasAuthorship W3096347524A5073575196 @default.
• W3096347524 hasBestOaLocation W30963475241 @default.
• W3096347524 hasConcept C104317684 @default.
• W3096347524 hasConcept C112705442 @default.
• W3096347524 hasConcept C126322002 @default.
• W3096347524 hasConcept C135763542 @default.
• W3096347524 hasConcept C140840227 @default.
• W3096347524 hasConcept C153209595 @default.
• W3096347524 hasConcept C2779548794 @default.
• W3096347524 hasConcept C2780690907 @default.
• W3096347524 hasConcept C54355233 @default.
• W3096347524 hasConcept C55775858 @default.
• W3096347524 hasConcept C71924100 @default.
• W3096347524 hasConcept C86803240 @default.
• W3096347524 hasConcept C89423630 @default.
• W3096347524 hasConcept C90924648 @default.
• W3096347524 hasConcept C92137452 @default.
• W3096347524 hasConcept C98274493 @default.
• W3096347524 hasConceptScore W3096347524C104317684 @default.
• W3096347524 hasConceptScore W3096347524C112705442 @default.
• W3096347524 hasConceptScore W3096347524C126322002 @default.
• W3096347524 hasConceptScore W3096347524C135763542 @default.
• W3096347524 hasConceptScore W3096347524C140840227 @default.
• W3096347524 hasConceptScore W3096347524C153209595 @default.
• W3096347524 hasConceptScore W3096347524C2779548794 @default.
• W3096347524 hasConceptScore W3096347524C2780690907 @default.
• W3096347524 hasConceptScore W3096347524C54355233 @default.
• W3096347524 hasConceptScore W3096347524C55775858 @default.
• W3096347524 hasConceptScore W3096347524C71924100 @default.
• W3096347524 hasConceptScore W3096347524C86803240 @default.
• W3096347524 hasConceptScore W3096347524C89423630 @default.
• W3096347524 hasConceptScore W3096347524C90924648 @default.
• W3096347524 hasConceptScore W3096347524C92137452 @default.
• W3096347524 hasConceptScore W3096347524C98274493 @default.
• W3096347524 hasIssue "6" @default.
• W3096347524 hasLocation W30963475241 @default.
• W3096347524 hasLocation W30963475242 @default.
• W3096347524 hasOpenAccess W3096347524 @default.

• next