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- W3096387398 abstract "Development of a tissue-engineered construct for hepatic regeneration remains a challenging task due to the lack of an optimum environment that support the growth of hepatocytes. Hydrogel systems possess many similarities with tissues and have the potential to provide the microenvironment essential for the cells to grow, proliferate, and remain functionally active. In this work, fibrin (FIB) incorporated injectable alginate dialdehyde (ADA) - gelatin (G) hydrogel was explored as a matrix for liver tissue engineering. ADA was prepared by periodate oxidation of sodium alginate. An injectable formulation of ADA-G-FIB hydrogel was prepared and characterized by FTIR spectroscopy, Scanning Electron Microscopy, and Micro-Computed Tomography. HepG2 cells were cultured on the hydrogel system; cellular growth and functions were analyzed using various functional markers. FTIR spectra of ADA-G-FIB depicted the formation of Schiff's base at 1608.53 cm −1 with a gelation time of 3 min. ADA-G-FIB depicted a 3D surface topography with a pore size in the range of 100–200 μm. The non-cytotoxic nature of the scaffold was demonstrated using L929 cells and more than 80 % cell viability was observed. Functional analysis of cultured HepG2 cells demonstrated ICG uptake, albumin synthesis, CYP-P450 expression, and ammonia clearance. ADA-G-FIB hydrogel can be used as an effective 3D scaffold system for liver tissue engineering." @default.
- W3096387398 created "2020-11-09" @default.
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- W3096387398 date "2021-01-01" @default.
- W3096387398 modified "2023-10-12" @default.
- W3096387398 title "Scaffold for liver tissue engineering: Exploring the potential of fibrin incorporated alginate dialdehyde–gelatin hydrogel" @default.
- W3096387398 cites W1503760388 @default.
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- W3096387398 cites W1974804788 @default.
- W3096387398 cites W1976788024 @default.
- W3096387398 cites W1979007572 @default.
- W3096387398 cites W1981893860 @default.
- W3096387398 cites W1984685797 @default.
- W3096387398 cites W1984804773 @default.
- W3096387398 cites W1985914247 @default.
- W3096387398 cites W1986507956 @default.
- W3096387398 cites W1989841129 @default.
- W3096387398 cites W1993417144 @default.
- W3096387398 cites W1999103801 @default.
- W3096387398 cites W2000862473 @default.
- W3096387398 cites W2003524810 @default.
- W3096387398 cites W2006009416 @default.
- W3096387398 cites W2008188168 @default.
- W3096387398 cites W2009222736 @default.
- W3096387398 cites W2011287971 @default.
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- W3096387398 cites W2038936977 @default.
- W3096387398 cites W2047866615 @default.
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- W3096387398 doi "https://doi.org/10.1016/j.ijbiomac.2020.10.256" @default.
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