FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096393429> ?p ?o ?g. }

• W3096393429 abstract "Hepatitis C virus (HCV) genotype 3 presents a high level of both baseline and acquired resistance to direct-acting antivirals (DAAs), particularly those targeting the NS5A protein. To understand this resistance we studied a cohort of Brazilian patients treated with the NS5A DAA, daclatasvir and the nucleoside analogue, sofosbuvir. We observed a novel substitution at NS5A amino acid residue 98 [serine to glycine (S98G)] in patients who relapsed post-treatment. The effect of this substitution on both replication fitness and resistance to DAAs was evaluated using two genotype 3 subgenomic replicons. S98G had a modest effect on replication, but in combination with the previously characterized resistance-associated substitution (RAS), Y93H, resulted in a significant increase in daclatasvir resistance. This result suggests that combinations of substitutions may drive a high level of DAA resistance and provide some clues to the mechanism of action of the NS5A-targeting DAAs." @default.
• W3096393429 created "2020-11-09" @default.
• W3096393429 creator A5031600734 @default.
• W3096393429 creator A5036008635 @default.
• W3096393429 creator A5043806503 @default.
• W3096393429 creator A5055031131 @default.
• W3096393429 creator A5063986268 @default.
• W3096393429 creator A5066249977 @default.
• W3096393429 creator A5076062989 @default.
• W3096393429 creator A5076252341 @default.
• W3096393429 creator A5078300463 @default.
• W3096393429 creator A5090487428 @default.
• W3096393429 date "2021-01-01" @default.
• W3096393429 modified "2023-10-15" @default.
• W3096393429 title "A novel substitution in NS5A enhances the resistance of hepatitis C virus genotype 3 to daclatasvir" @default.
• W3096393429 cites W1993681618 @default.
• W3096393429 cites W1995591620 @default.
• W3096393429 cites W2012808888 @default.
• W3096393429 cites W2096347191 @default.
• W3096393429 cites W2119571917 @default.
• W3096393429 cites W2134472003 @default.
• W3096393429 cites W2166962970 @default.
• W3096393429 cites W2344854262 @default.
• W3096393429 cites W2468776796 @default.
• W3096393429 cites W2495212599 @default.
• W3096393429 cites W2570488703 @default.
• W3096393429 cites W2757637661 @default.
• W3096393429 cites W2784952994 @default.
• W3096393429 cites W3000235286 @default.
• W3096393429 cites W3084207277 @default.
• W3096393429 doi "https://doi.org/10.1099/jgv.0.001496" @default.
• W3096393429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8116786" @default.
• W3096393429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33141008" @default.
• W3096393429 hasPublicationYear "2021" @default.
• W3096393429 type Work @default.
• W3096393429 sameAs 3096393429 @default.
• W3096393429 citedByCount "1" @default.
• W3096393429 countsByYear W30963934292022 @default.
• W3096393429 crossrefType "journal-article" @default.
• W3096393429 hasAuthorship W3096393429A5031600734 @default.
• W3096393429 hasAuthorship W3096393429A5036008635 @default.
• W3096393429 hasAuthorship W3096393429A5043806503 @default.
• W3096393429 hasAuthorship W3096393429A5055031131 @default.
• W3096393429 hasAuthorship W3096393429A5063986268 @default.
• W3096393429 hasAuthorship W3096393429A5066249977 @default.
• W3096393429 hasAuthorship W3096393429A5076062989 @default.
• W3096393429 hasAuthorship W3096393429A5076252341 @default.
• W3096393429 hasAuthorship W3096393429A5078300463 @default.
• W3096393429 hasAuthorship W3096393429A5090487428 @default.
• W3096393429 hasBestOaLocation W30963934291 @default.
• W3096393429 hasConcept C104317684 @default.
• W3096393429 hasConcept C114851261 @default.
• W3096393429 hasConcept C135763542 @default.
• W3096393429 hasConcept C159047783 @default.
• W3096393429 hasConcept C18103114 @default.
• W3096393429 hasConcept C22744801 @default.
• W3096393429 hasConcept C2522874641 @default.
• W3096393429 hasConcept C2776408679 @default.
• W3096393429 hasConcept C2776979040 @default.
• W3096393429 hasConcept C2777103181 @default.
• W3096393429 hasConcept C2778390639 @default.
• W3096393429 hasConcept C2780040827 @default.
• W3096393429 hasConcept C2781463415 @default.
• W3096393429 hasConcept C2993683473 @default.
• W3096393429 hasConcept C501734568 @default.
• W3096393429 hasConcept C54355233 @default.
• W3096393429 hasConcept C86803240 @default.
• W3096393429 hasConceptScore W3096393429C104317684 @default.
• W3096393429 hasConceptScore W3096393429C114851261 @default.
• W3096393429 hasConceptScore W3096393429C135763542 @default.
• W3096393429 hasConceptScore W3096393429C159047783 @default.
• W3096393429 hasConceptScore W3096393429C18103114 @default.
• W3096393429 hasConceptScore W3096393429C22744801 @default.
• W3096393429 hasConceptScore W3096393429C2522874641 @default.
• W3096393429 hasConceptScore W3096393429C2776408679 @default.
• W3096393429 hasConceptScore W3096393429C2776979040 @default.
• W3096393429 hasConceptScore W3096393429C2777103181 @default.
• W3096393429 hasConceptScore W3096393429C2778390639 @default.
• W3096393429 hasConceptScore W3096393429C2780040827 @default.
• W3096393429 hasConceptScore W3096393429C2781463415 @default.
• W3096393429 hasConceptScore W3096393429C2993683473 @default.
• W3096393429 hasConceptScore W3096393429C501734568 @default.
• W3096393429 hasConceptScore W3096393429C54355233 @default.
• W3096393429 hasConceptScore W3096393429C86803240 @default.
• W3096393429 hasFunder F4320320997 @default.
• W3096393429 hasFunder F4320322725 @default.
• W3096393429 hasIssue "1" @default.
• W3096393429 hasLocation W30963934291 @default.
• W3096393429 hasLocation W30963934292 @default.
• W3096393429 hasLocation W30963934293 @default.
• W3096393429 hasLocation W30963934294 @default.
• W3096393429 hasOpenAccess W3096393429 @default.
• W3096393429 hasPrimaryLocation W30963934291 @default.
• W3096393429 hasRelatedWork W2786448332 @default.
• W3096393429 hasRelatedWork W2793782584 @default.
• W3096393429 hasRelatedWork W2888376303 @default.
• W3096393429 hasRelatedWork W2901511423 @default.
• W3096393429 hasRelatedWork W2914965217 @default.
• W3096393429 hasRelatedWork W2942417030 @default.
• W3096393429 hasRelatedWork W2974160651 @default.

• next