FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096408052> ?p ?o ?g. }

• W3096408052 endingPage "3523" @default.
• W3096408052 startingPage "3523" @default.
• W3096408052 abstract "Diabetic retinopathy (DR) has traditionally been viewed as either a microvasculopathy or a neuropathy, though neurovascular coupling deficits have also been reported and could potentially be the earliest derangement in DR. To better understand neurovascular coupling in the diabetic retina, we investigated retinal hemodynamics by optical coherence tomography angiography (OCTA) in individuals with diabetes mellitus (DM) but without DR (DM no DR) and mild non-proliferative DR (mild NPDR) compared to healthy eyes. Using an experimental design to monitor the capillary responses during transition from dark adaptation to light, we examined 19 healthy, 14 DM no DR and 11 mild NPDR individuals. We found that the only structural vascular abnormality in the DM no DR group was increased superficial capillary plexus (SCP) vessel density (VD) compared to healthy eyes, while mild NPDR eyes showed significant vessel loss in the SCP at baseline. There was no significant difference in inner retinal thickness between the groups. During dark adaptation, the deep capillary plexus (DCP) VD was lower in mild NPDR individuals compared to the other two groups, which may leave the photoreceptors more susceptible to ischemia in the dark. When transitioning from dark to ambient light, both diabetic groups showed a qualitative reversal of VD trends in the SCP and middle capillary plexus (MCP), with significantly decreased SCP at 5 min and increased MCP VD at 50 s compared to healthy eyes, which may impede metabolic supply to the inner retina during light adaptation. Mild NPDR eyes also demonstrated DCP dilation at 50 s and 5 min and decreased adjusted flow index at 5 min in light. Our results show altered neurovascular responses in all three macular vascular plexuses in diabetic subjects in the absence of structural neuronal changes on high resolution imaging, suggesting that neurovascular uncoupling may be a key mechanism in the early pathogenesis of DR, well before the clinical appearance of vascular or neuronal loss." @default.
• W3096408052 created "2020-11-09" @default.
• W3096408052 creator A5028340203 @default.
• W3096408052 creator A5043641379 @default.
• W3096408052 creator A5050641912 @default.
• W3096408052 creator A5060709755 @default.
• W3096408052 creator A5061627322 @default.
• W3096408052 creator A5068286008 @default.
• W3096408052 creator A5079152380 @default.
• W3096408052 date "2020-10-31" @default.
• W3096408052 modified "2023-10-17" @default.
• W3096408052 title "Reversed Neurovascular Coupling on Optical Coherence Tomography Angiography Is the Earliest Detectable Abnormality before Clinical Diabetic Retinopathy" @default.
• W3096408052 cites W1569974693 @default.
• W3096408052 cites W1897240354 @default.
• W3096408052 cites W1964267325 @default.
• W3096408052 cites W1965743404 @default.
• W3096408052 cites W1966206262 @default.
• W3096408052 cites W1982020416 @default.
• W3096408052 cites W1983924090 @default.
• W3096408052 cites W1985870422 @default.
• W3096408052 cites W1992868980 @default.
• W3096408052 cites W1996921085 @default.
• W3096408052 cites W2001727667 @default.
• W3096408052 cites W2003723664 @default.
• W3096408052 cites W2004831170 @default.
• W3096408052 cites W2006163606 @default.
• W3096408052 cites W2011540186 @default.
• W3096408052 cites W2021041589 @default.
• W3096408052 cites W2028254185 @default.
• W3096408052 cites W2045161931 @default.
• W3096408052 cites W2058083259 @default.
• W3096408052 cites W2076061064 @default.
• W3096408052 cites W2082533150 @default.
• W3096408052 cites W2099540110 @default.
• W3096408052 cites W2099831846 @default.
• W3096408052 cites W2099961792 @default.
• W3096408052 cites W2118479818 @default.
• W3096408052 cites W2120487349 @default.
• W3096408052 cites W2123108580 @default.
• W3096408052 cites W2163234334 @default.
• W3096408052 cites W2164036805 @default.
• W3096408052 cites W2165373379 @default.
• W3096408052 cites W2170914099 @default.
• W3096408052 cites W2171480988 @default.
• W3096408052 cites W2195194158 @default.
• W3096408052 cites W2283184966 @default.
• W3096408052 cites W2315117775 @default.
• W3096408052 cites W2342880967 @default.
• W3096408052 cites W2399208400 @default.
• W3096408052 cites W2461701740 @default.
• W3096408052 cites W2502457878 @default.
• W3096408052 cites W2553926324 @default.
• W3096408052 cites W2554093589 @default.
• W3096408052 cites W2568525740 @default.
• W3096408052 cites W2587570425 @default.
• W3096408052 cites W2597124360 @default.
• W3096408052 cites W2609340129 @default.
• W3096408052 cites W2610359265 @default.
• W3096408052 cites W2765604220 @default.
• W3096408052 cites W2767388526 @default.
• W3096408052 cites W2781485997 @default.
• W3096408052 cites W2801088543 @default.
• W3096408052 cites W2849298850 @default.
• W3096408052 cites W2885562029 @default.
• W3096408052 cites W2889527980 @default.
• W3096408052 cites W2902491562 @default.
• W3096408052 cites W2912128752 @default.
• W3096408052 cites W2913806328 @default.
• W3096408052 cites W2915410141 @default.
• W3096408052 cites W2922732764 @default.
• W3096408052 cites W2954946691 @default.
• W3096408052 cites W2966067209 @default.
• W3096408052 cites W2970447084 @default.
• W3096408052 cites W2989356389 @default.
• W3096408052 cites W3003314574 @default.
• W3096408052 cites W3013718377 @default.
• W3096408052 cites W3018404308 @default.
• W3096408052 cites W3019067474 @default.
• W3096408052 cites W3082829149 @default.
• W3096408052 cites W46138929 @default.
• W3096408052 cites W65306218 @default.
• W3096408052 cites W86558771 @default.
• W3096408052 cites W93258804 @default.
• W3096408052 doi "https://doi.org/10.3390/jcm9113523" @default.
• W3096408052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7692675" @default.
• W3096408052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33142724" @default.
• W3096408052 hasPublicationYear "2020" @default.
• W3096408052 type Work @default.
• W3096408052 sameAs 3096408052 @default.
• W3096408052 citedByCount "11" @default.
• W3096408052 countsByYear W30964080522021 @default.
• W3096408052 countsByYear W30964080522022 @default.
• W3096408052 countsByYear W30964080522023 @default.
• W3096408052 crossrefType "journal-article" @default.
• W3096408052 hasAuthorship W3096408052A5028340203 @default.
• W3096408052 hasAuthorship W3096408052A5043641379 @default.
• W3096408052 hasAuthorship W3096408052A5050641912 @default.
• W3096408052 hasAuthorship W3096408052A5060709755 @default.

• next