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- W3096436701 abstract "A novel and efficient biocatalyzed methodology for the construction of functionalized quinazolinone derivatives via tandem / hydrolysis / decarboxylation / cyclization and transesterification reactions has been developed that works with a variety of 2-aminobenzamide and β-dicarbonyl compounds. This method requires mild conditions, and has demonstrated high catalytic activity, excellent yields, excellent chemoselectivity, and a broad substrate scope. Additionally, biocatalyzed decarboxylation does not require high temperatures or light activation, giving it a substantial advantage over alternative techniques. Most importantly, it offers a new example for the exploration of simple, convenient, and environmentally friendly synthetic routes utilizing enzymes in organic chemistry." @default.
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- W3096436701 date "2020-12-01" @default.
- W3096436701 modified "2023-09-26" @default.
- W3096436701 title "Selective synthesis of functionalized quinazolinone derivatives via biocatalysis" @default.
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- W3096436701 doi "https://doi.org/10.1016/j.mcat.2020.111261" @default.
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