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- W3096510680 endingPage "108757" @default.
- W3096510680 startingPage "108757" @default.
- W3096510680 abstract "Bile acids (BAs) are amphiphilic molecules with a nonpolar steroid carbon skeleton and a polar carboxylate side chain. Recently, BAs have aroused the attention of scholars due to their potential roles on metabolic diseases. As important endogenous ligands, BAs are wildly active in the enterohepatic circulation, during which microbiota play a significant role in promoting the hydrolysis and dehydroxylation of BAs. Besides, many pathways initiated by BAs including glucolipid metabolism and inflammation signaling pathways have been reported to regulate the host metabolism and maintain immune homeostasis. Herein, the characteristics on the enterohepatic circulation and metabolism of BAs are systematically summarized. Moreover, the regulation mechanism of the glucolipid metabolism by BAs is intensively discussed. Worthily, FXR and TGR5, which are involved in glucolipid metabolism, are the prime candidates for targeted therapies of chronic metabolic diseases such as diabetes and hypercholesterolemia." @default.
- W3096510680 created "2020-11-09" @default.
- W3096510680 creator A5003181280 @default.
- W3096510680 creator A5003360183 @default.
- W3096510680 creator A5031980964 @default.
- W3096510680 creator A5040817687 @default.
- W3096510680 creator A5042290112 @default.
- W3096510680 creator A5049139494 @default.
- W3096510680 creator A5064313538 @default.
- W3096510680 date "2021-01-01" @default.
- W3096510680 modified "2023-10-15" @default.
- W3096510680 title "Enterohepatic circulation of bile acids and their emerging roles on glucolipid metabolism" @default.
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