Matches in SemOpenAlex for { <https://semopenalex.org/work/W3096584903> ?p ?o ?g. }
- W3096584903 endingPage "1530" @default.
- W3096584903 startingPage "1514" @default.
- W3096584903 abstract "Gliomas are the most common primary brain tumors in adults. They are generally very resistant to treatment and are therefore associated with negative outcomes. MicroRNAs (miRNAs) are small, non-coding RNA molecules that affect many cellular processes by regulating gene expression and, post-transcriptionally, the translation of mRNAs. MiRNA-21 has been consistently shown to be upregulated in glioma and research has shown that it is involved in a wide variety of biological pathways, promoting tumor cell survival and invasiveness. Furthermore, it has been implicated in resistance to treatment, both against chemotherapy and radiotherapy. In this review, we gathered the existent data on miRNA-21 and gliomas, in terms of its expression levels, association with grade and prognosis, the pathways it involves and its targets in glioma, and finally how it leads to treatment resistance. Furthermore, we discuss how this knowledge could be applied in clinical practice in the years to come. To our knowledge, this is the first review to assess in extent and depth the role of miRNA-21 in gliomas." @default.
- W3096584903 created "2020-11-09" @default.
- W3096584903 creator A5008228820 @default.
- W3096584903 creator A5018705575 @default.
- W3096584903 creator A5032161433 @default.
- W3096584903 creator A5032663940 @default.
- W3096584903 creator A5035560002 @default.
- W3096584903 creator A5046916516 @default.
- W3096584903 creator A5048093545 @default.
- W3096584903 creator A5048983300 @default.
- W3096584903 creator A5070098215 @default.
- W3096584903 creator A5074264303 @default.
- W3096584903 creator A5082937280 @default.
- W3096584903 date "2020-01-01" @default.
- W3096584903 modified "2023-10-02" @default.
- W3096584903 title "The role of MiRNA-21 in gliomas: Hope for a novel therapeutic intervention?" @default.
- W3096584903 cites W1514512256 @default.
- W3096584903 cites W1520292475 @default.
- W3096584903 cites W1566823022 @default.
- W3096584903 cites W1574172480 @default.
- W3096584903 cites W1648301895 @default.
- W3096584903 cites W1791554167 @default.
- W3096584903 cites W1857468337 @default.
- W3096584903 cites W1893588436 @default.
- W3096584903 cites W1965735982 @default.
- W3096584903 cites W1968325334 @default.
- W3096584903 cites W1972193661 @default.
- W3096584903 cites W1972380031 @default.
- W3096584903 cites W1972430277 @default.
- W3096584903 cites W1972892962 @default.
- W3096584903 cites W1973222840 @default.
- W3096584903 cites W1975901832 @default.
- W3096584903 cites W1978393771 @default.
- W3096584903 cites W1979646626 @default.
- W3096584903 cites W1979842763 @default.
- W3096584903 cites W1986187057 @default.
- W3096584903 cites W1988692970 @default.
- W3096584903 cites W1990079648 @default.
- W3096584903 cites W1995291683 @default.
- W3096584903 cites W1996672337 @default.
- W3096584903 cites W1998006834 @default.
- W3096584903 cites W1999553354 @default.
- W3096584903 cites W2001755595 @default.
- W3096584903 cites W2003832896 @default.
- W3096584903 cites W2006628284 @default.
- W3096584903 cites W2007214287 @default.
- W3096584903 cites W2009303494 @default.
- W3096584903 cites W2010180766 @default.
- W3096584903 cites W2018088692 @default.
- W3096584903 cites W2018093166 @default.
- W3096584903 cites W2019846650 @default.
- W3096584903 cites W2019913217 @default.
- W3096584903 cites W2022551564 @default.
- W3096584903 cites W2025370055 @default.
- W3096584903 cites W2028251568 @default.
- W3096584903 cites W2030842519 @default.
- W3096584903 cites W2031482209 @default.
- W3096584903 cites W2033541023 @default.
- W3096584903 cites W2033797433 @default.
- W3096584903 cites W2037038224 @default.
- W3096584903 cites W2039234610 @default.
- W3096584903 cites W2040323141 @default.
- W3096584903 cites W2040572868 @default.
- W3096584903 cites W2041708367 @default.
- W3096584903 cites W2042681244 @default.
- W3096584903 cites W2047581475 @default.
- W3096584903 cites W2047972729 @default.
- W3096584903 cites W2048554743 @default.
- W3096584903 cites W2049813036 @default.
- W3096584903 cites W2052828768 @default.
- W3096584903 cites W2053676995 @default.
- W3096584903 cites W2054506446 @default.
- W3096584903 cites W2056015659 @default.
- W3096584903 cites W2057470417 @default.
- W3096584903 cites W2058328925 @default.
- W3096584903 cites W2058940095 @default.
- W3096584903 cites W2061399161 @default.
- W3096584903 cites W2066570761 @default.
- W3096584903 cites W2070023993 @default.
- W3096584903 cites W2075543095 @default.
- W3096584903 cites W2080652879 @default.
- W3096584903 cites W2080713919 @default.
- W3096584903 cites W2080852268 @default.
- W3096584903 cites W2081297751 @default.
- W3096584903 cites W2085690580 @default.
- W3096584903 cites W2085910493 @default.
- W3096584903 cites W2087802327 @default.
- W3096584903 cites W2088170612 @default.
- W3096584903 cites W2090395289 @default.
- W3096584903 cites W2091108445 @default.
- W3096584903 cites W2092264059 @default.
- W3096584903 cites W2095801710 @default.
- W3096584903 cites W2097617161 @default.
- W3096584903 cites W2098877258 @default.
- W3096584903 cites W2099467660 @default.
- W3096584903 cites W2101698500 @default.
- W3096584903 cites W2103052577 @default.
- W3096584903 cites W2103744931 @default.