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- W3096604804 abstract "Purpose To analysis, daidzein increases the expression of bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor 2 (Runx2) after experimental tooth movement (EXTM).Materials and Methods 36 Wistar rats were randomly divided into the EXTM group and EXTM with daidzein group (EXTM+DZ group). After EXTM, the rats in the EXTM+DZ group were treated with daidzein (10 mg/kg/day). Micro-computed tomography (CT) analysis revealed the bone mineral density (BMD), ratio of bone volume to tissue volume (BV/TV), and ratio of relapse. Histopathological changes were examined by immunohistochemical staining for BMP-2 and Runx2. Human PDLCs were subjected to tension force and treated with 10 μg/mL daidzein. The expression of BMP-2 and Runx2 by daidzein was confirmed by real-time polymerase chain reaction and enzyme-linked immunosorbent assay.Results The EXTM+DZ group showed a significantly decreased ratio of relapse and increased BMD and BV/TV as compared to the EXTM group. The ratio of BMP-2 – and Runx-2 –positive cells in the EXTM+DZ group was higher than that in the EXTM group. Moreover, daidzein upregulated the mRNA expression and protein levels of BMP-2 and Runx2 in a time-dependent manner.Conclusion These results suggested that daidzein decreased the ratio of relapse through BMP-2 and Runx2 expression." @default.
- W3096604804 created "2020-11-09" @default.
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- W3096604804 date "2020-10-27" @default.
- W3096604804 modified "2023-10-18" @default.
- W3096604804 title "Daidzein induces bone morphogenetic protein-2 and runt-related transcription 2 on periodontal ligament cells after experimental tooth movement" @default.
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- W3096604804 doi "https://doi.org/10.1080/13440241.2020.1839208" @default.
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