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- W3096684977 abstract "ABSTRACT Long-lasting long-term potentiation (L-LTP) is a cellular mechanism of learning and memory storage. Studies have demonstrated a requirement for extracellular signal-regulated kinase (ERK) activation in L-LTP produced by a diversity of temporal stimulation patterns. Multiple signaling pathways converge to activate ERK, with different pathways being required for different stimulation patterns. To answer whether and how different temporal patterns select different signaling pathways for ERK activation, we developed a computational model of five signaling pathways (including two novel pathways) leading to ERK activation during L-LTP induction. We show that calcium and cAMP work synergistically to activate ERK and that stimuli given with large inter-trial intervals activate more ERK than shorter intervals. Furthermore, these pathways contribute to different dynamics of ERK activation. These results suggest that signaling pathways with different temporal sensitivity facilitate ERK activation to diversity of temporal patterns." @default.
- W3096684977 created "2020-11-09" @default.
- W3096684977 creator A5054745889 @default.
- W3096684977 creator A5090861565 @default.
- W3096684977 date "2020-11-04" @default.
- W3096684977 modified "2023-10-18" @default.
- W3096684977 title "Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction" @default.
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- W3096684977 doi "https://doi.org/10.1101/2020.11.04.368571" @default.
- W3096684977 hasPublicationYear "2020" @default.
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